Periodontitis and diabetes associations with measures of atherosclerosis and CHD

• Published in: Atherosclerosis 2012-05, Vol.222 (1), p.196-201
• Main Authors: Southerland, Janet H, Moss, Kevin, Taylor, George W, Beck, James D, Pankow, James, Gangula, Pandu R, Offenbacher, Steven
• Format: Article
• Language: English
• Subjects: Acoustic shadowing; acoustics; Aged; Associated diseases and complications; atherosclerosis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; body mass index; calcification; Cardiology. Vascular system; Cardiovascular; carotid arteries; Carotid Intima-Media Thickness; Coronary Artery Disease - etiology; coronary disease; Coronary Disease - complications; Coronary Disease - etiology; Coronary heart disease; diabetes; Diabetes Complications; Diabetes Mellitus - pathology; Diabetes. Impaired glucose tolerance; education; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; gender; high density lipoprotein cholesterol; Humans; hypertension; income; Inflammatory mediators; Intimal–medial wall thickness; low density lipoprotein; Male; Medical sciences; Metabolic control; Middle Aged; multivariate analysis; people; Periodontal disease; periodontal diseases; Periodontitis - complications; Periodontitis - epidemiology; Periodontitis - pathology; regression analysis; Risk; triacylglycerols; United States - epidemiology
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2012.01.026

Highlights ► Severe periodontal disease and diabetes is associated with increased prevalence of IMT ≥ 1, acoustic shadowing, and CHD. ► Diabetes alone is associated with increased odds for IMT > 1 mm, but not shadowing or CHD. ► Periodontal disease increases the likelihood of subclinical atherosclerotic heart disease and CHD in diabetic patients. ► There is a need case definitions of periodontal disease that effectively capture systemic effects of sever forms of the disease. ► Further investigation is warranted to understand the interaction of diabetes and periodontal disease as it relates to increased prevalence of IMT, acoustic shadowing, and CHD.