Characterization of a carcinogenesis-associated long non-coding RNA

A negative selection strategy was used in the present study to isolate long polyA-minus RNAs from the total transcriptome and a long non-coding RNA named Yiya was identified. Yiya is a 1.9 kb long intergenic ncRNA gene mapped to chromosome 1q41, a well-established cancer susceptibility locus. Expres...

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Bibliographic Details
Published in:RNA biology 2012-01, Vol.9 (1), p.110-116
Main Authors: Yang, Feng, Yi, Fan, Zheng, Zhiguo, Ling, Zhiqiang, Ding, Jianv, Guo, Jiangfeng, Mao, Weimin, Wang, Xiongbiao, Wang, Xiaoxia, Ding, Xianfeng, Liang, Zicai, Du, Quan
Format: Article
Language:English
Subjects:
Binding
Biology
Biomarkers, Tumor - analysis
Biomarkers, Tumor - genetics
Bioscience
Calcium
Cancer
Case-Control Studies
Cell
Cell Cycle
Chromosomes, Human, Pair 1 - genetics
Cloning, Molecular
Cycle
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genetic Vectors
Genome, Human
HEK293 Cells
HeLa Cells
Humans
Landes
long non-coding RNA
Neoplasms - genetics
Organogenesis
Proteins
RNA, Messenger - analysis
RNA, Messenger - genetics
RNA, Neoplasm - genetics
RNA, Untranslated - genetics
Transfection
tumor
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Summary:A negative selection strategy was used in the present study to isolate long polyA-minus RNAs from the total transcriptome and a long non-coding RNA named Yiya was identified. Yiya is a 1.9 kb long intergenic ncRNA gene mapped to chromosome 1q41, a well-established cancer susceptibility locus. Expression profiling revealed a general and regulated expression pattern of Yiya in major tissues, and more interestingly, identified elevated mRNA levels in different cancers. Quantitative analysis further demonstrated a dynamic regulation of Yiya expression in cell cycle progression, suggesting that it was involved in cell cycle regulation. Supporting this, overexpression of Yiya promotes cell cycle progression at the G1/S transition, therefore identifying Yiya as a cell-cycle-associated long non-coding RNA.
ISSN:1547-6286
1555-8584
DOI:10.4161/rna.9.1.18332