PRENATAL EPOXICONAZOLE EXPOSURE EFFECTS ON RAT POSTNATAL DEVELOPMENT

Although some studies have pointed out to embryo/fetal toxicity, knowledge about the potential toxicity of the fungicide epoxiconazole is still limited. Once the results of these previous studies have raised some concern, this study studied the effects of epoxiconazole maternal exposure on the physi...

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Published in:Birth defects research. Part B. Developmental and reproductive toxicology 2012-04, Vol.95 (2), p.123-129
Main Authors: de Castro, Vera L.S.S., Maia, Aline H.
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn - growth & development
biomarkers
developmental toxicity
Dose-Response Relationship, Drug
endocrine disruptor
Endocrine Disruptors - toxicity
epoxiconazole prenatal exposure
Epoxy Compounds - toxicity
Female
Fungicides, Industrial - toxicity
Lactation
Linear Models
Male
Organogenesis - drug effects
Pregnancy
Prenatal Exposure Delayed Effects
rat
Rats
Rats, Wistar
reproduction
Reproduction - drug effects
teratogenic effects
Triazoles - toxicity
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Summary:Although some studies have pointed out to embryo/fetal toxicity, knowledge about the potential toxicity of the fungicide epoxiconazole is still limited. Once the results of these previous studies have raised some concern, this study studied the effects of epoxiconazole maternal exposure on the physical endpoints in the development of rat pups. To accomplish that, the effects of epoxiconazole (50.0, 100.0, and 150.0 mg/kg) were examined when rats were exposed at two different developmental stages: during the first 6 days of pregnancy or in the organogenesis period (6–15 days). After parturition, pups were tested for growth and maturational milestones. Maternal exposure to the fungicide, independently of phase, resulted in significantly early mean time to vaginal opening and delayed time to testes descent in pups. Weight gain rate in pups and their mothers was not affected for the tested exposure period. The findings of this study emphasize that epoxiconazole maternal exposure may lead to alterations in developmental patterns in nursing pups, consistent with the known influence of epoxiconazole on steroid hormone synthesis. Birth Defects Res (Part B) XX:1–7 © 2011 Wiley Periodicals, Inc.
ISSN:1542-9733
1542-9741
DOI:10.1002/bdrb.20345