Granulocyte Colony-Stimulating Factor Expressing Retroperitoneal Dedifferentiated Liposarcoma

Because soft-tissue tumors associated with a leukemoid reaction are uncommon, we could review only a few cases of liposarcoma with a leukocytosis in the English literature.3, 4 All of them documented that tumors were mainly comprised of poorly differentiated components and that the poorly differenti...

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Bibliographic Details
Published in:The American surgeon 2012-03, Vol.78 (3), p.375-376
Main Authors: MONMA, Satoko, ADACHI, Kensuke, HASHIMOTO, Takuya, OHSHIMA, Akira
Format: Article
Language:English
Subjects:
Abdomen
Aged
Biological and medical sciences
Biomarkers, Tumor - blood
Dermatology
Family medical history
Female
General aspects
Granulocyte Colony-Stimulating Factor - blood
Humans
Liposarcoma - blood
Liposarcoma - diagnostic imaging
Liposarcoma - surgery
Medical sciences
Neoplasm Recurrence, Local - blood
Neoplasm Recurrence, Local - diagnostic imaging
Radiography
Retroperitoneal Neoplasms - blood
Retroperitoneal Neoplasms - diagnostic imaging
Retroperitoneal Neoplasms - surgery
Tumors
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Because soft-tissue tumors associated with a leukemoid reaction are uncommon, we could review only a few cases of liposarcoma with a leukocytosis in the English literature.3, 4 All of them documented that tumors were mainly comprised of poorly differentiated components and that the poorly differentiated character was increasingly observed during a relapse. 3 There might be the possible implication between undifferentiated character of malignant cells and hematopoietic differentiation, resulting in acquisition of G-CSF production. [...]G-CSF could also modify microenvironments around the tumor cells, which may be advantageous for tumor progression.
ISSN:0003-1348
1555-9823
DOI:10.1177/000313481207800353