Oral neurovascular hamartoma: a lesion searching for a name

J Oral Pathol Med (2012) 41: 348–353 Background:  Neurovascular hamartoma (NVH), in particular in the oral cavity, is rarely described in the literature. The low number of cases may reflect a genuine rarity of the lesion, or it may be due to its being unrecognized and/or under‐reported. Objectives: ...

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Bibliographic Details
Published in:Journal of oral pathology & medicine 2012-04, Vol.41 (4), p.348-353
Main Authors: Allon, Irit, Allon, Dror M., Hirshberg, Avraham, Shlomi, Benjamin, Lifschitz-Mercer, Beatriz, Kaplan, Ilana
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Child
choristoma
Dentistry
Diagnosis, Differential
Female
hamartoma
Hamartoma - pathology
Humans
Hyperplasia
irritation fibroma
Lip Diseases - pathology
Male
Medical sciences
Microvessels - pathology
Middle Aged
Mouth Diseases - pathology
Mouth Mucosa - blood supply
Mouth Mucosa - innervation
Mouth Mucosa - pathology
Nerve Fibers - pathology
neurovascular
Otorhinolaryngology. Stomatology
Rare Diseases
Retrospective Studies
Terminology as Topic
Tongue Diseases - pathology
Young Adult
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Summary:J Oral Pathol Med (2012) 41: 348–353 Background:  Neurovascular hamartoma (NVH), in particular in the oral cavity, is rarely described in the literature. The low number of cases may reflect a genuine rarity of the lesion, or it may be due to its being unrecognized and/or under‐reported. Objectives:  To investigate clinical and microscopic features of oral NVH and to define microscopic diagnostic criteria with emphasis on the differential diagnosis. Methods:  Archival cases diagnosed as oral NVH between 1999 and 2011 were retrieved; clinical and demographic data were collected, and a paired morphometric analysis was conducted, with each case of NVH a case of fibrous hyperplasia (FH) from the same oral location. The nerve bundle and blood vessel density were quantified in five microscopic fields at ×100 magnification. Results:  The study group included 25 oral NVH, 11 men and 14 women, aged 6–76 years, (mean 44). The majority occurred in the tongue (54%), followed by the buccal mucosa and lower lip (17% each), clinically presenting as asymptomatic 0.25–2.5 cm exophytic masses. Microscopic characteristics included poorly circumscribed masses of closely packed nerve bundles and blood vessels in a loose matrix, containing minimal or no inflammation. The mean nerve bundle density was significantly higher in NVH (4.28 ± 1.26) in comparison with FH (0.27 ± 0.27), (P 
ISSN:0904-2512
1600-0714
DOI:10.1111/j.1600-0714.2011.01101.x