Effects of Aging on Angiogenesis

Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of both cardiovascular diseases and their adverse sequelae in the elderly. Angiogenesis is both an essential adaptive response to...

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Bibliographic Details
Published in:Circulation research 2012-04, Vol.110 (9), p.1252-1264
Main Authors: Lähteenvuo, Johanna, Rosenzweig, Anthony
Format: Article
Language:English
Subjects:
Age Factors
Aging - metabolism
Angiogenic Proteins - metabolism
Animals
Biological and medical sciences
Cardiovascular Diseases - etiology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - physiopathology
Cardiovascular Diseases - therapy
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor Proteins - metabolism
Fundamental and applied biological sciences. Psychology
Humans
Neovascularization, Physiologic
Nitric Oxide - metabolism
Oxidative Stress
Risk Factors
Signal Transduction
Vertebrates: cardiovascular system
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Summary:Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of both cardiovascular diseases and their adverse sequelae in the elderly. Angiogenesis is both an essential adaptive response to physiological stress and an endogenous repair mechanism after ischemic injury. In addition, induction of angiogenesis is a promising therapeutic approach for ischemic diseases. For these reasons, understanding the basis of age-related impairment of angiogenesis and endothelial function has important implications for understanding and managing cardiovascular disease. In this review, we discuss the molecular mechanisms that contribute to impaired angiogenesis in the elderly and potential therapeutic approaches to improving vascular function and angiogenesis in aging patients.
ISSN:0009-7330
1524-4571
DOI:10.1161/CIRCRESAHA.111.246116