Cadherins in brain morphogenesis and wiring

Cadherins are Ca(2+)-dependent cell-cell adhesion molecules that play critical roles in animal morphogenesis. Various cadherin-related molecules have also been identified, which show diverse functions, not only for the regulation of cell adhesion but also for that of cell proliferation and planar ce...

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Bibliographic Details
Published in:Physiological reviews 2012-04, Vol.92 (2), p.597-634
Main Authors: Hirano, Shinji, Takeichi, Masatoshi
Format: Article
Language:English
Subjects:
Animals
Brain
Brain - growth & development
Brain - physiology
Cadherins - physiology
Cell adhesion & migration
Cell Adhesion - physiology
Cell Polarity - physiology
Cell Proliferation
Gene Expression Regulation, Developmental - physiology
Humans
Mice
Molecules
Morphogenesis
Nervous system
Vertebrates
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Summary:Cadherins are Ca(2+)-dependent cell-cell adhesion molecules that play critical roles in animal morphogenesis. Various cadherin-related molecules have also been identified, which show diverse functions, not only for the regulation of cell adhesion but also for that of cell proliferation and planar cell polarity. During the past decade, understanding of the roles of these molecules in the nervous system has significantly progressed. They are important not only for the development of the nervous system but also for its functions and, in turn, for neural disorders. In this review, we discuss the roles of cadherins and related molecules in neural development and function in the vertebrate brain.
ISSN:0031-9333
1522-1210
DOI:10.1152/physrev.00014.2011