Tim-2 up-regulation and galectin-9-Tim-3 pathway activation in Th2-biased response in Schistosoma japonicum infection in mice

Highlights ► An original and innovative research on Th2-biased immune response and pathogenic mechanisms of schistosomiasis is present. ► Areas in immunology that may benefit from immune-regulatory effects induced by the helminth–schistosome are also discussed.

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Bibliographic Details
Published in:Immunology letters 2012-05, Vol.144 (1), p.60-66
Main Authors: Qi, Yao, Song, Xiao-rong, Shen, Ji-long, Xu, Yuan-hong, Shen, Qian, Luo, Qing-li, Zhong, Zheng-rong, Wang, Wei, Chu, De-yong, Song, Wen-jian
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Apoptosis
Cell Differentiation
Female
Galectin-9
Galectins - genetics
Galectins - metabolism
Hepatitis A Virus Cellular Receptor 2
Membrane Proteins - genetics
Membrane Proteins - metabolism
Mice
Mice, Inbred BALB C
Receptors, Virus - genetics
Receptors, Virus - metabolism
Schistosoma japonicum - immunology
Schistosoma japonicum - pathogenicity
Schistosomiasis
Schistosomiasis japonica - immunology
Schistosomiasis japonica - parasitology
Schistosomiasis japonica - physiopathology
T cell immunoglobulin domain and mucin domain
T-Lymphocytes - cytology
T-Lymphocytes - immunology
T-Lymphocytes - physiology
Th2 Cells - immunology
Th2 Cells - metabolism
Th2-biased response
Up-Regulation
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Description
Summary:Highlights ► An original and innovative research on Th2-biased immune response and pathogenic mechanisms of schistosomiasis is present. ► Areas in immunology that may benefit from immune-regulatory effects induced by the helminth–schistosome are also discussed.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2012.03.007