Unexplained infertility: Association with inherited thrombophilia

Abstract Introduction Unexplained infertility represents one of the most common diagnoses in fertility care. Attention is being paid to the association between inherited thrombophilia and infertility causes. In this study we investigated the prevalence of inherited thrombophilia according to inferti...

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Bibliographic Details
Published in:Thrombosis research 2012-05, Vol.129 (5), p.e185-e188
Main Authors: Fatini, Cinzia, Conti, Lucia, Turillazzi, Valentina, Sticchi, Elena, Romagnuolo, Ilaria, Milanini, Maria Novella, Cozzi, Cinzia, Abbate, Rosanna, Noci, Ivo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Female
Female and unexplained infertility
Genetic Predisposition to Disease
Hematology, Oncology and Palliative Medicine
Humans
Infertility, Female - blood
Infertility, Female - epidemiology
Infertility, Female - genetics
Inherited thrombophilia
Italy - epidemiology
Male
Middle Aged
Prevalence
Prothrombin gene mutation
Risk Factors
Thrombophilia - epidemiology
Thrombophilia - genetics
Young Adult
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Summary:Abstract Introduction Unexplained infertility represents one of the most common diagnoses in fertility care. Attention is being paid to the association between inherited thrombophilia and infertility causes. In this study we investigated the prevalence of inherited thrombophilia according to infertility causes. Materials and methods We studied Prothrombin gene G20210A mutation, Factor V Leiden, deficiencies in protein S and C and antithrombin in 930 Caucasian infertile women referred to Fertility Center of the Department of Sciences for Woman and Child's Health, University of Florence, of whom 230 with unexplained, 195 female and 283 male infertility, and in 240 women who have conceived naturally without hormonal stimulation therapy. Results A significant relationship between inherited thrombophilia [OR 95%CI 1.97 (1.05-3.68), p = 0.03] and unexplained infertility was observed, whereas no association between thrombophilia and female and male infertility was found. Significantly higher prevalence of prothrombin gene mutation in unexplained infertile women in comparison to that observed in fertile women was observed (5.7% vs 2.1% p = 0.04); the prevalence of the other thrombophilia determinants was higher, even if not significantly, in the unexplained infertile group. Conclusions This study demonstrates the relationship between inherited thrombophilia and unexplained infertility, thus suggesting the contribution of genetic components in modulating unexplained infertility, behind anovulation, male and tubal factor.
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2012.02.012