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Role of quaternary ammonium salts as new additives in the enantioselective organocatalytic β-benzylation of enals
We report herein the efficiency of quaternary ammonium salts as co-catalysts in organocatalytic Michael reactions involving iminium activation of α,β-unsaturated aldehydes. The enantioselective formal benzylation of these substrates has been optimized and used to rationalize the role of the ammonium...
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Published in: | Chemical communications (Cambridge, England) England), 2012-05, Vol.48 (42), p.5184-5186 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | We report herein the efficiency of quaternary ammonium salts as co-catalysts in organocatalytic Michael reactions involving iminium activation of α,β-unsaturated aldehydes. The enantioselective formal benzylation of these substrates has been optimized and used to rationalize the role of the ammonium salts in these processes. |
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ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/c2cc31451g |