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Role of quaternary ammonium salts as new additives in the enantioselective organocatalytic β-benzylation of enals

We report herein the efficiency of quaternary ammonium salts as co-catalysts in organocatalytic Michael reactions involving iminium activation of α,β-unsaturated aldehydes. The enantioselective formal benzylation of these substrates has been optimized and used to rationalize the role of the ammonium...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-05, Vol.48 (42), p.5184-5186
Main Authors: Duce, Sara, Mateo, Alvaro, Alonso, Inés, García Ruano, José Luis, Cid, M Belén
Format: Article
Language:English
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Summary:We report herein the efficiency of quaternary ammonium salts as co-catalysts in organocatalytic Michael reactions involving iminium activation of α,β-unsaturated aldehydes. The enantioselective formal benzylation of these substrates has been optimized and used to rationalize the role of the ammonium salts in these processes.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc31451g