US-guided percutaneous thrombin injection of postcatheterization pseudoaneurysms

• Published in: Diagnostic and interventional radiology (Ankara, Turkey) Turkey), 2012-05, Vol.18 (3), p.319-325
• Main Authors: Gürel, Kamil, Gür, Serkan, Özkan, Uğur, Tekbaş, Güven, Önder, Hakan, Oğuzkurt, Levent
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Aneurysm, False - drug therapy; Aneurysm, False - etiology; Brachial Artery - diagnostic imaging; Catheterization - adverse effects; Female; Femoral Artery - diagnostic imaging; Humans; Injections - methods; Male; Middle Aged; Retrospective Studies; Thrombin - administration & dosage; Ultrasonography, Interventional
• ISSN: 1305-3825; 1305-3612
• DOI: 10.4261/1305-3825.DIR.4933-11.1

This study retrospectively evaluated ultrasonography-guided (US-guided) percutaneous thrombin injection for the treatment of postcatheterization femoral and brachial artery pseudoaneurysms. Fifty-five patients with postcatheterization femoral artery (n = 53) or brachial artery (n = 2) pseudoaneurysms were treated using US-guided human thrombin (500 IU/mL) injection. Pseudoaneurysm size, thrombin dose, therapy outcome, and complications were documented. Follow-up color Doppler US was performed 7 and 30 days after treatment. Short-duration supplemental compression was applied to six patients at the first week follow-up examination after a reinjection of thrombin had failed. Mean pseudoaneurysm volume was 20.3 ± 18.7 cm(3). The mean injected thrombin dose was 478 ± 238 IU. Thirty-eight (69.1%) of the 55 pseudoaneurysms were thrombosed with a single injection, and 11 of 17 pseudoaneurysms were thrombosed after a second injection. All (100%) of the 41 pseudoaneurysms that were diagnosed within the first two weeks of postcatheterization were successfully treated. The overall primary success rate was 89.1% (49 of 55 pseudoaneurysms). Supplemental compression promoted thrombosis in four of the six patients who had treatment failure with thrombin injection. The secondary success rate was 96.4% (53 of 55 pseudoaneurysms). There were no complications. US-guided thrombin injection was most successful within the first two weeks, and the supplemental compression might aid in the closure of partially thrombosed pseudoaneurysms.