A case of severe oral self-injurious Tourette's syndrome alleviated by pregabalin

Abstract Self-injurious behavior (SIB) associated with Tourette's syndrome (TS) is a severe neuropsychiatric condition that causes significant distress and can impair social functioning. The current treatment options for the condition include pharmacological, physical and psychosocial intervent...

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Bibliographic Details
Published in:General hospital psychiatry 2012-05, Vol.34 (3), p.321.e1-321.e4
Main Authors: Fornaro, Michele, M.D, Maremmani, Angelo Giovanni Icro, M.D, Colicchio, Maria Giovanna, M.D, Romano, Anna, M.D, Fornaro, Stefania, M.D, Rizzato, Salvatore, M.D, Ciampa, Giovanni, M.D, Colicchio, Salvatore, M.D, Dell'Osso, Liliana, M.D
Format: Article
Language:English
Subjects:
Anticonvulsants - administration & dosage
Anticonvulsants - therapeutic use
gamma-Aminobutyric Acid - administration & dosage
gamma-Aminobutyric Acid - analogs & derivatives
gamma-Aminobutyric Acid - therapeutic use
Humans
Male
Middle Aged
Mouth - injuries
Pregabalin
Psychiatry
Self-Injurious Behavior - drug therapy
Self-Injurious Behavior - physiopathology
Self-injury
Severity of Illness Index
Tourette Syndrome - complications
Tourette's syndrome
Treatment Outcome
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Summary:Abstract Self-injurious behavior (SIB) associated with Tourette's syndrome (TS) is a severe neuropsychiatric condition that causes significant distress and can impair social functioning. The current treatment options for the condition include pharmacological, physical and psychosocial interventions. However, given the need for more effective interventions, especially for those patients who are unresponsive and/or intolerant to standard medications, further exploration of novel treatments is imperative. In this report, we present a case of SIB-TS that was successfully treated with pregabalin. The patient received 1-year of follow-up and was noted to have considerable improvement in symptoms. Although rigorous controlled studies are required, based on our case study, pregabalin may be a potential treatment option in some cases of SIB with TS.
ISSN:0163-8343
1873-7714
DOI:10.1016/j.genhosppsych.2011.10.003