The use of TachoSil for the prevention of postoperative complications after groin dissection in cases of gynecologic malignancy

• Published in: International journal of gynecology and obstetrics 2012-06, Vol.117 (3), p.217-219
• Main Authors: Buda, Alessandro, Fruscio, Robert, Pirovano, Cecilia, Signorelli, Mauro, Betti, Marta, Milani, Rodolfo
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Antibiotic Prophylaxis; Biological and medical sciences; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Case-Control Studies; Cellulitis - etiology; Cellulitis - prevention & control; Drainage; Drug Combinations; Female; Fibrinogen - therapeutic use; Groin; Gynecologic malignancy; Gynecology. Andrology. Obstetrics; Humans; Inguinofemoral groin dissection; Lymph Node Excision - adverse effects; Lymphedema - etiology; Lymphedema - prevention & control; Lymphocele - etiology; Lymphocele - prevention & control; Medical sciences; Middle Aged; Obstetrics and Gynecology; Ovarian Neoplasms - pathology; Ovarian Neoplasms - surgery; Postoperative complications; Surgical patch; Surgical Sponges; Surgical Wound Dehiscence - etiology; Surgical Wound Dehiscence - prevention & control; Surgical Wound Infection - etiology; Surgical Wound Infection - prevention & control; Thrombin - therapeutic use; Vulvar Neoplasms - pathology; Vulvar Neoplasms - surgery
• ISSN: 0020-7292; 1879-3479
• DOI: 10.1016/j.ijgo.2011.12.021

Abstract Objective To evaluate the effect of TachoSil in preventing postoperative complications after groin dissection performed for primary or recurrent gynecologic malignancy. Methods In a case–control analysis, the incidence of postoperative complications—including lymphocyst formation, wound breakdown and/or infection, and chronic lymphedema—was examined among 8 patients who received TachoSil and 16 controls (standard technique) treated for vulvar cancer or recurrent ovarian/breast cancer at San Gerardo Hospital, Monza, Italy, from 2008 to 2011. Results Thirty-eight inguinal dissections were performed in the 24 patients. Bilateral groin dissection was performed in 14 patients (n = 4 in the study group; n = 10 in the control group). Patients in the study group had a lower mean daily drainage volume than those in the control group (133 mL [range, 50–356 mL] vs 320 mL [range, 67–472 mL]; P < 0.001) and a lower incidence of lymphocyst requiring drainage (25.0% vs 62.5%), cellulitis (12.0% vs 25.0%), and wound infection (0.0% vs 25.0%). Conclusion The use of TachoSil seems to be effective in reducing the rate of postoperative complications after inguinofemoral lymphadenectomy in cases of gynecologic malignancy.