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Increase of choroidal and scleral MCP-1 expression in hypercholesterolemia experimental model

The aim of this study is to experientially demonstrate that a cholesterol-enriched diet induces an increase in the MCP-1 expression in the choroid and sclera. New Zealand rabbits were divided into two groups: GN (normal diet group) of 8 rabbits (8 eyes) was fed a standard rabbit diet for 4 weeks; GH...

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Published in:	Arquivos brasileiros de oftalmologia 2012-01, Vol.75 (1), p.48-52
Main Authors:	Torres, Rogil José de Almeida, Noronha, Lucia de, Casella, Antonio Marcelo Barbante, Lumikoski, Thaís Isabel, Précoma, Leonardo Brandão, Torres, Caroline Luzia de Almeida, Luchini, Andréa, Sturzeneker, Mario Claudio Soares, Précoma, Dalton Bertolim
Format:	Article
Language:	Portuguese
Subjects:	Animals Chemokine CCL2 - metabolism Cholesterol, Dietary - adverse effects Choroid - metabolism Disease Models, Animal Hypercholesterolemia - etiology Hypercholesterolemia - metabolism Immunohistochemistry Male Rabbits Sclera - metabolism
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container_title	Arquivos brasileiros de oftalmologia
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creator	Torres, Rogil José de Almeida Noronha, Lucia de Casella, Antonio Marcelo Barbante Lumikoski, Thaís Isabel Précoma, Leonardo Brandão Torres, Caroline Luzia de Almeida Luchini, Andréa Sturzeneker, Mario Claudio Soares Précoma, Dalton Bertolim
description	The aim of this study is to experientially demonstrate that a cholesterol-enriched diet induces an increase in the MCP-1 expression in the choroid and sclera. New Zealand rabbits were divided into two groups: GN (normal diet group) of 8 rabbits (8 eyes) was fed a standard rabbit diet for 4 weeks; GH (hypercholesterolemic group) of 13 rabbits (13 eyes) was fed a 1% cholesterol enriched diet for 8 weeks. Total serum cholesterol, triglyceride, HDL cholesterol and fasting blood glucose exams were performed at the start of the experiment and at the euthanasia time. After GH 8th week and GN 4th week animals were euthanized and their eyes underwent immunohistochemical analysis with the anti-MCP-1 antibody. The diet has induced a significant increase in GH total cholesterol and triglyceride levels when compared with NG (p
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subjects	Animals Chemokine CCL2 - metabolism Cholesterol, Dietary - adverse effects Choroid - metabolism Disease Models, Animal Hypercholesterolemia - etiology Hypercholesterolemia - metabolism Immunohistochemistry Male Rabbits Sclera - metabolism
title	Increase of choroidal and scleral MCP-1 expression in hypercholesterolemia experimental model
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