The activity of the inosine triphosphate pyrophosphatase affects toxicity of 6-mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children

Abstract The association between inosine triphosphate pyrophosphatase (ITPA) activity and toxicity of 6-mercaptopurine (6-MP) was retrospectively evaluated in 65 Japanese children with acute lymphoblastic leukemia (ALL). Patients with an ITPA activity of less than 126 μmol/h/gHb presented with hepat...

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Bibliographic Details
Published in:Leukemia research 2012-05, Vol.36 (5), p.560-564
Main Authors: Tanaka, Yoichi, Manabe, Atsushi, Nakadate, Hisaya, Kondoh, Kensuke, Nakamura, Kozue, Koh, Katsuyoshi, Utano, Tomoyuki, Kikuchi, Akira, Komiyama, Takako
Format: Article
Language:English
Subjects:
6-Mercaptopurine
Acute lymphoblastic leukemia
Adolescent
Antimetabolites, Antineoplastic - adverse effects
Child
Child, Preschool
Enzyme activity
Female
Hematology, Oncology and Palliative Medicine
Humans
Infant
Inosine triphosphate pyrophosphatase
Maintenance therapy
Male
Mercaptopurine - adverse effects
Multi-center study
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Pyrophosphatases - metabolism
Retrospective Studies
Toxicity
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Summary:Abstract The association between inosine triphosphate pyrophosphatase (ITPA) activity and toxicity of 6-mercaptopurine (6-MP) was retrospectively evaluated in 65 Japanese children with acute lymphoblastic leukemia (ALL). Patients with an ITPA activity of less than 126 μmol/h/gHb presented with hepatotoxicity more frequently than those with higher ITPA activity ( p < 0.01). The average 6-MP dose during maintenance therapy administered to two patients with the ITPA deficiency was lower than that given to the other patients. Measuring ITPA activity is important for ensuring the safety of maintenance therapy for Asians with ALL because thiopurine S-methyl transferase mutations are rare in the Asian population.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2011.11.015