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Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals
Aims/hypothesis Variants of the high-mobility group A1 ( HMGA1 ) gene have been shown to be associated with insulin resistance and type 2 diabetes in individuals of European origin. We aimed to determine whether this locus confers significant susceptibility to type 2 diabetes in the Han Chinese popu...
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| Published in: | Diabetologia 2012-06, Vol.55 (6), p.1685-1688 |
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| Main Authors: | , , , , , , , , |
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| container_end_page | 1688 |
| container_issue | 6 |
| container_start_page | 1685 |
| container_title | Diabetologia |
| container_volume | 55 |
| creator | Liu, L. Ding, H. Wang, H. R. Xu, Y. J. Cui, G. L. Wang, P. H. Yuan, G. Yu, X. F. Wang, D. W. |
| description | Aims/hypothesis
Variants of the high-mobility group A1 (
HMGA1
) gene have been shown to be associated with insulin resistance and type 2 diabetes in individuals of European origin. We aimed to determine whether this locus confers significant susceptibility to type 2 diabetes in the Han Chinese population, and thus cross-race susceptibility to type 2 diabetes.
Methods
Polymorphisms in
HMGA1
were identified by direct sequencing of genomic DNA derived from 192 Chinese participants (96 patients with type 2 diabetes and 96 controls). We then genotyped the common variant IVS5-13insC (c.136-14_136-13insC) in two other independent cohorts, including a total of 2,533 cases and 2,643 ethnically matched controls.
Results
We confirmed the association of the
HMGA1
variant IVS5-13insC (c.136-14_136-13insC) with type 2 diabetes with an OR of 1.34 (95% CI 1.15, 1.56,
p
= 0.0002 under a dominant model, and 95% CI 1.16, 1.55,
p
= 0.0002 under an additive model) in the Han Chinese population, corresponding to a population attributable risk fraction of 5.0%.
Conclusions/interpretation
HMGA1
is an important susceptibility locus that confers a high cross-race risk of the development of type 2 diabetes. |
| doi_str_mv | 10.1007/s00125-012-2518-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1011542189</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1011542189</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-79afadfe935703d931be3fe2e7c7789432d230d0b244f85398a1a81d15404acb3</originalsourceid><addsrcrecordid>eNp1kV2L1TAQhoMo7tnVH-CNBETYm2omH216uRx0V1jRCwXvStpM92Rtm2OmVc6_N-UcPxC8mSHM876Z5GXsGYhXIET1moQAaYpcCmnAFuIB24BWshBa2odss44LsOWXM3ZOdC-EUEaXj9mZlBoAVLlh_mMcDmNM-12gkcee37y_vgIeiDui2AU3o-c_wrzjYeoSOsrHFOjris6HPXLJfXAtzpgVY5zu-HYXJiTMvA_fg1_cQE_Yoz43fHrqF-zz2zeftjfF7Yfrd9ur26LT2sxFVbve-R5rZSqhfK2gRdWjxKqrKlvnh3mphBet1Lq3RtXWgbPgwWihXdeqC3Z59N2n-G1BmpsxUIfD4CaMCzUgILMSbJ3RF_-g93FJU95upZQutSxNpuBIdSkSJeybfQqjS4cMNWsEzTGCJpdmjaARWfP85Ly0I_rfil9_noGXJ8BR54Y-uakL9Icz1lalXo3kkaM8mu4w_b3i_27_CdXenHc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1013464265</pqid></control><display><type>article</type><title>Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals</title><source>Springer Nature</source><creator>Liu, L. ; Ding, H. ; Wang, H. R. ; Xu, Y. J. ; Cui, G. L. ; Wang, P. H. ; Yuan, G. ; Yu, X. F. ; Wang, D. W.</creator><creatorcontrib>Liu, L. ; Ding, H. ; Wang, H. R. ; Xu, Y. J. ; Cui, G. L. ; Wang, P. H. ; Yuan, G. ; Yu, X. F. ; Wang, D. W.</creatorcontrib><description>Aims/hypothesis
Variants of the high-mobility group A1 (
HMGA1
) gene have been shown to be associated with insulin resistance and type 2 diabetes in individuals of European origin. We aimed to determine whether this locus confers significant susceptibility to type 2 diabetes in the Han Chinese population, and thus cross-race susceptibility to type 2 diabetes.
Methods
Polymorphisms in
HMGA1
were identified by direct sequencing of genomic DNA derived from 192 Chinese participants (96 patients with type 2 diabetes and 96 controls). We then genotyped the common variant IVS5-13insC (c.136-14_136-13insC) in two other independent cohorts, including a total of 2,533 cases and 2,643 ethnically matched controls.
Results
We confirmed the association of the
HMGA1
variant IVS5-13insC (c.136-14_136-13insC) with type 2 diabetes with an OR of 1.34 (95% CI 1.15, 1.56,
p
= 0.0002 under a dominant model, and 95% CI 1.16, 1.55,
p
= 0.0002 under an additive model) in the Han Chinese population, corresponding to a population attributable risk fraction of 5.0%.
Conclusions/interpretation
HMGA1
is an important susceptibility locus that confers a high cross-race risk of the development of type 2 diabetes.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s00125-012-2518-0</identifier><identifier>PMID: 22411136</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Asian Continental Ancestry Group - genetics ; Biological and medical sciences ; Diabetes ; Diabetes Mellitus, Type 2 - genetics ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Genotype ; HMGA Proteins - genetics ; Human Physiology ; Humans ; Insulin resistance ; Internal Medicine ; Male ; Medical records ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Polymorphism ; Polymorphism, Genetic - genetics ; Short Communication</subject><ispartof>Diabetologia, 2012-06, Vol.55 (6), p.1685-1688</ispartof><rights>Springer-Verlag 2012</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-79afadfe935703d931be3fe2e7c7789432d230d0b244f85398a1a81d15404acb3</citedby><cites>FETCH-LOGICAL-c445t-79afadfe935703d931be3fe2e7c7789432d230d0b244f85398a1a81d15404acb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25887640$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22411136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, L.</creatorcontrib><creatorcontrib>Ding, H.</creatorcontrib><creatorcontrib>Wang, H. R.</creatorcontrib><creatorcontrib>Xu, Y. J.</creatorcontrib><creatorcontrib>Cui, G. L.</creatorcontrib><creatorcontrib>Wang, P. H.</creatorcontrib><creatorcontrib>Yuan, G.</creatorcontrib><creatorcontrib>Yu, X. F.</creatorcontrib><creatorcontrib>Wang, D. W.</creatorcontrib><title>Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><addtitle>Diabetologia</addtitle><description>Aims/hypothesis
Variants of the high-mobility group A1 (
HMGA1
) gene have been shown to be associated with insulin resistance and type 2 diabetes in individuals of European origin. We aimed to determine whether this locus confers significant susceptibility to type 2 diabetes in the Han Chinese population, and thus cross-race susceptibility to type 2 diabetes.
Methods
Polymorphisms in
HMGA1
were identified by direct sequencing of genomic DNA derived from 192 Chinese participants (96 patients with type 2 diabetes and 96 controls). We then genotyped the common variant IVS5-13insC (c.136-14_136-13insC) in two other independent cohorts, including a total of 2,533 cases and 2,643 ethnically matched controls.
Results
We confirmed the association of the
HMGA1
variant IVS5-13insC (c.136-14_136-13insC) with type 2 diabetes with an OR of 1.34 (95% CI 1.15, 1.56,
p
= 0.0002 under a dominant model, and 95% CI 1.16, 1.55,
p
= 0.0002 under an additive model) in the Han Chinese population, corresponding to a population attributable risk fraction of 5.0%.
Conclusions/interpretation
HMGA1
is an important susceptibility locus that confers a high cross-race risk of the development of type 2 diabetes.</description><subject>Adult</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Genotype</subject><subject>HMGA Proteins - genetics</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical records</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Short Communication</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp1kV2L1TAQhoMo7tnVH-CNBETYm2omH216uRx0V1jRCwXvStpM92Rtm2OmVc6_N-UcPxC8mSHM876Z5GXsGYhXIET1moQAaYpcCmnAFuIB24BWshBa2odss44LsOWXM3ZOdC-EUEaXj9mZlBoAVLlh_mMcDmNM-12gkcee37y_vgIeiDui2AU3o-c_wrzjYeoSOsrHFOjris6HPXLJfXAtzpgVY5zu-HYXJiTMvA_fg1_cQE_Yoz43fHrqF-zz2zeftjfF7Yfrd9ur26LT2sxFVbve-R5rZSqhfK2gRdWjxKqrKlvnh3mphBet1Lq3RtXWgbPgwWihXdeqC3Z59N2n-G1BmpsxUIfD4CaMCzUgILMSbJ3RF_-g93FJU95upZQutSxNpuBIdSkSJeybfQqjS4cMNWsEzTGCJpdmjaARWfP85Ly0I_rfil9_noGXJ8BR54Y-uakL9Icz1lalXo3kkaM8mu4w_b3i_27_CdXenHc</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Liu, L.</creator><creator>Ding, H.</creator><creator>Wang, H. R.</creator><creator>Xu, Y. J.</creator><creator>Cui, G. L.</creator><creator>Wang, P. H.</creator><creator>Yuan, G.</creator><creator>Yu, X. F.</creator><creator>Wang, D. W.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals</title><author>Liu, L. ; Ding, H. ; Wang, H. R. ; Xu, Y. J. ; Cui, G. L. ; Wang, P. H. ; Yuan, G. ; Yu, X. F. ; Wang, D. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-79afadfe935703d931be3fe2e7c7789432d230d0b244f85398a1a81d15404acb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biological and medical sciences</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Genotype</topic><topic>HMGA Proteins - genetics</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical records</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Short Communication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, L.</creatorcontrib><creatorcontrib>Ding, H.</creatorcontrib><creatorcontrib>Wang, H. R.</creatorcontrib><creatorcontrib>Xu, Y. J.</creatorcontrib><creatorcontrib>Cui, G. L.</creatorcontrib><creatorcontrib>Wang, P. H.</creatorcontrib><creatorcontrib>Yuan, G.</creatorcontrib><creatorcontrib>Yu, X. F.</creatorcontrib><creatorcontrib>Wang, D. W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, L.</au><au>Ding, H.</au><au>Wang, H. R.</au><au>Xu, Y. J.</au><au>Cui, G. L.</au><au>Wang, P. H.</au><au>Yuan, G.</au><au>Yu, X. F.</au><au>Wang, D. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals</atitle><jtitle>Diabetologia</jtitle><stitle>Diabetologia</stitle><addtitle>Diabetologia</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>55</volume><issue>6</issue><spage>1685</spage><epage>1688</epage><pages>1685-1688</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>Aims/hypothesis
Variants of the high-mobility group A1 (
HMGA1
) gene have been shown to be associated with insulin resistance and type 2 diabetes in individuals of European origin. We aimed to determine whether this locus confers significant susceptibility to type 2 diabetes in the Han Chinese population, and thus cross-race susceptibility to type 2 diabetes.
Methods
Polymorphisms in
HMGA1
were identified by direct sequencing of genomic DNA derived from 192 Chinese participants (96 patients with type 2 diabetes and 96 controls). We then genotyped the common variant IVS5-13insC (c.136-14_136-13insC) in two other independent cohorts, including a total of 2,533 cases and 2,643 ethnically matched controls.
Results
We confirmed the association of the
HMGA1
variant IVS5-13insC (c.136-14_136-13insC) with type 2 diabetes with an OR of 1.34 (95% CI 1.15, 1.56,
p
= 0.0002 under a dominant model, and 95% CI 1.16, 1.55,
p
= 0.0002 under an additive model) in the Han Chinese population, corresponding to a population attributable risk fraction of 5.0%.
Conclusions/interpretation
HMGA1
is an important susceptibility locus that confers a high cross-race risk of the development of type 2 diabetes.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22411136</pmid><doi>10.1007/s00125-012-2518-0</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-186X |
| ispartof | Diabetologia, 2012-06, Vol.55 (6), p.1685-1688 |
| issn | 0012-186X 1432-0428 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1011542189 |
| source | Springer Nature |
| subjects | Adult Aged Asian Continental Ancestry Group - genetics Biological and medical sciences Diabetes Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Genotype HMGA Proteins - genetics Human Physiology Humans Insulin resistance Internal Medicine Male Medical records Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Polymorphism Polymorphism, Genetic - genetics Short Communication |
| title | Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals |
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