Biocompatible Zwitterionic Sulfobetaine Copolymer-Coated Mesoporous Silica Nanoparticles for Temperature-Responsive Drug Release

A novel nanocontainer, which could regulate the release of payloads, has been successfully fabricated by attaching zwitterionic sulfobetaine copolymer onto the mesoporous silica nanoparticles (MSNs). RAFT polymerization is employed to prepare the hybrid poly(2‐(dimethylamino)ethyl methacrylate)‐coat...

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Bibliographic Details
Published in:Macromolecular rapid communications. 2012-05, Vol.33 (9), p.811-818
Main Authors: Sun, Jiao-Tong, Yu, Zhi-Qiang, Hong, Chun-Yan, Pan, Cai-Yuan
Format: Article
Language:English
Subjects:
Betaine - analogs & derivatives
Betaine - chemical synthesis
Betaine - chemistry
Betaine - toxicity
Cell Survival - drug effects
controlled release
core-shell nanoparticles
Delayed-Action Preparations
Drug Delivery Systems
HeLa Cells
Humans
Methacrylates - chemistry
Nanocapsules - chemistry
Nanocapsules - toxicity
Nanocapsules - ultrastructure
Nanoparticles
Nylons - chemistry
Polymerization
Polymethacrylic Acids - chemical synthesis
Polymethacrylic Acids - chemistry
Polymethacrylic Acids - toxicity
Porous materials
RAFT polymerization
Rhodamines - chemistry
Silica
Silicon Dioxide - chemistry
smart polymers
Spectroscopy, Fourier Transform Infrared
Temperature
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Summary:A novel nanocontainer, which could regulate the release of payloads, has been successfully fabricated by attaching zwitterionic sulfobetaine copolymer onto the mesoporous silica nanoparticles (MSNs). RAFT polymerization is employed to prepare the hybrid poly(2‐(dimethylamino)ethyl methacrylate)‐coated MSNs (MSN‐PDMAEMA). Subsequently, the tertiary amine groups in PDMAEMA are quaternized with 1,3‐propanesultone to get poly(DMAEMA‐co‐3‐dimethyl(methacryloyloxyethyl)ammonium propanesulfonate)‐coated MSNs [MSN‐Poly(DMAEMA‐co‐DMAPS)]. The zwitterionic PDMAPS component endows the nanocarrier with biocompatibility, and the PDMAEMA component makes the copolymer shell temperature‐responsive. Controlled release of loaded rhodamine B has been achieved in the saline solutions. The biocompatible ampholytic copolymer has been grafted onto the mesoporous silica nanoparticles via surface RAFT polymerization. The dual thermo‐sensitive copolymer shell behaves specially with the increasing temperature. Thermoresponsive release of payload from the novel nanocarrier has been studied in this paper.
ISSN:1022-1336
1521-3927
DOI:10.1002/marc.201100876