Biocompatible Zwitterionic Sulfobetaine Copolymer-Coated Mesoporous Silica Nanoparticles for Temperature-Responsive Drug Release

• Published in: Macromolecular rapid communications. 2012-05, Vol.33 (9), p.811-818
• Main Authors: Sun, Jiao-Tong, Yu, Zhi-Qiang, Hong, Chun-Yan, Pan, Cai-Yuan
• Format: Article
• Language: English
• Subjects: Betaine - analogs & derivatives; Betaine - chemical synthesis; Betaine - chemistry; Betaine - toxicity; Cell Survival - drug effects; controlled release; core-shell nanoparticles; Delayed-Action Preparations; Drug Delivery Systems; HeLa Cells; Humans; Methacrylates - chemistry; Nanocapsules - chemistry; Nanocapsules - toxicity; Nanocapsules - ultrastructure; Nanoparticles; Nylons - chemistry; Polymerization; Polymethacrylic Acids - chemical synthesis; Polymethacrylic Acids - chemistry; Polymethacrylic Acids - toxicity; Porous materials; RAFT polymerization; Rhodamines - chemistry; Silica; Silicon Dioxide - chemistry; smart polymers; Spectroscopy, Fourier Transform Infrared; Temperature
• ISSN: 1022-1336; 1521-3927
• DOI: 10.1002/marc.201100876

A novel nanocontainer, which could regulate the release of payloads, has been successfully fabricated by attaching zwitterionic sulfobetaine copolymer onto the mesoporous silica nanoparticles (MSNs). RAFT polymerization is employed to prepare the hybrid poly(2‐(dimethylamino)ethyl methacrylate)‐coated MSNs (MSN‐PDMAEMA). Subsequently, the tertiary amine groups in PDMAEMA are quaternized with 1,3‐propanesultone to get poly(DMAEMA‐co‐3‐dimethyl(methacryloyloxyethyl)ammonium propanesulfonate)‐coated MSNs [MSN‐Poly(DMAEMA‐co‐DMAPS)]. The zwitterionic PDMAPS component endows the nanocarrier with biocompatibility, and the PDMAEMA component makes the copolymer shell temperature‐responsive. Controlled release of loaded rhodamine B has been achieved in the saline solutions. The biocompatible ampholytic copolymer has been grafted onto the mesoporous silica nanoparticles via surface RAFT polymerization. The dual thermo‐sensitive copolymer shell behaves specially with the increasing temperature. Thermoresponsive release of payload from the novel nanocarrier has been studied in this paper.