Thin-section chest CT findings in systemic lupus erythematosus with antiphospholipid syndrome: A comparison with systemic lupus erythematosus without antiphospholipid syndrome

Abstract Purpose To assess thin-section chest CT findings in systemic lupus erythematosus (SLE) with antiphospholipid syndrome (APS), in comparison with SLE without APS. Materials and methods We retrospectively reviewed the medical records and thin-section CT findings of 17 consecutive patients with...

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Bibliographic Details
Published in:European journal of radiology 2012-06, Vol.81 (6), p.1335-1339
Main Authors: Oki, Hodaka, Aoki, Takatoshi, Saito, Kazuyoshi, Yamashita, Yoshiko, Hanamiya, Mai, Hayashida, Yoshiko, Tanaka, Yoshiya, Korogi, Yukunori
Format: Article
Language:English
Subjects:
Adult
Antiphospholipid syndrome
Antiphospholipid Syndrome - complications
Antiphospholipid Syndrome - diagnostic imaging
Computed tomography
Female
Humans
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - diagnostic imaging
Male
Middle Aged
Radiography, Thoracic
Radiology
Retrospective Studies
Systemic lupus erythematosus
Tomography, X-Ray Computed - methods
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Summary:Abstract Purpose To assess thin-section chest CT findings in systemic lupus erythematosus (SLE) with antiphospholipid syndrome (APS), in comparison with SLE without APS. Materials and methods We retrospectively reviewed the medical records and thin-section CT findings of 17 consecutive patients with an established diagnosis of SLE with APS, comparing with 37 consecutive SLE patients without APS, between 2004 and 2008, and patients who had other autoimmune disease, such as Sjögren syndrome, were excluded. No significant differences were seen between the two groups in age, gender, smoking habits, or history of steroid pulse and biological therapy. CT images of 2 mm thickness obtained with a 16- or 64-detector row CT were retrospectively evaluated by two radiologists in consensus on ultra high-resolution gray-scale monitors. Results The frequency of thin-section CT abnormalities was higher in SLE with APS group (82%) than in SLE without APS group (43%). Ground-glass opacity (59%), architectural distortion (47%), reticulation (41%), enlarged peripheral pulmonary artery (29%), and mosaic attenuation (29%) were significantly more common in the SLE with APS group than in the SLE without APS group (Fisher's exact test, p < 0.01). Conclusion SLE patients with APS have increased prevalence of thin-section chest CT abnormalities than those without APS.
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2011.03.041