Discovery and development of N-cadherin antagonists

This article describes over 20 years of research on antagonists of the cell adhesion molecule, N-cadherin. Four types of antagonists are discussed: synthetic linear peptides, synthetic cyclic peptides, non-peptidyl peptidomimetics of the disulfide linked cyclic peptide N-Ac-CHAVC-NH2 and monoclonal...

Full description

Saved in:
Bibliographic Details
Published in:Cell and tissue research 2012-05, Vol.348 (2), p.309-313
Main Author: Blaschuk, Orest W
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Angiogenesis inhibitors
antagonists
antineoplastic agents
Biomedical and Life Sciences
Biomedicine
Cadherins - antagonists & inhibitors
Cancer
cell adhesion
Cell adhesion & migration
cyclic peptides
Drug therapy
Human Genetics
Humans
Medical research
Mini Review
Molecular Medicine
Monoclonal antibodies
Peptides
Peptides - chemistry
Peptides - pharmacology
Proteomics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This article describes over 20 years of research on antagonists of the cell adhesion molecule, N-cadherin. Four types of antagonists are discussed: synthetic linear peptides, synthetic cyclic peptides, non-peptidyl peptidomimetics of the disulfide linked cyclic peptide N-Ac-CHAVC-NH2 and monoclonal antibodies directed against the N-cadherin ectodomain. The biological activities of these antagonists are also discussed. In particular, the ability of N-cadherin antagonists to act as anti-cancer drugs is considered.
ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-011-1320-5