In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strai...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-06, Vol.48 (45), p.5674-5676
Main Authors: Matthes, Diana, Richter, Lennart, Müller, Jane, Denisiuk, Alexander, Feifel, Sven C, Xu, Yuquan, Espinosa-Artiles, Patricia, Süssmuth, Roderich D, Molnár, István
Format: Article
Language:English
Subjects:
Beauveria - chemistry
Beauveria - enzymology
Beauveria - genetics
Biocatalysis
Cloning, Molecular
Depsipeptides - chemistry
Depsipeptides - metabolism
Escherichia coli - genetics
Mutation
Peptide Synthases - genetics
Peptide Synthases - metabolism
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Summary:New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc31669b