The pyruvate dehydrogenase complex as a therapeutic target for age‐related diseases

Summary Considerable research has been conducted on mitochondrial biology as it pertains to aging. However, relatively little attention has been accorded the pyruvate dehydrogenase complex (PDC) relative to how we grow old and acquire age‐related diseases. The purpose of this review is threefold: fi...

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Bibliographic Details
Published in:Aging cell 2012-06, Vol.11 (3), p.371-377
Main Author: Stacpoole, Peter W.
Format: Article
Language:English
Subjects:
Age Factors
aging
Alzheimer Disease - enzymology
Alzheimer’s disease
Animals
Caenorhabditis elegans
cancer
Dehydrogenases
dichloroacetate
Genes
glucose intolerance
Humans
Medical research
mitochondria
Mitochondria - drug effects
Mitochondria - enzymology
Molecular Targeted Therapy
Neoplasms - enzymology
pyruvate dehydrogenase complex
Pyruvate Dehydrogenase Complex - metabolism
Pyruvate Dehydrogenase Complex Deficiency Disease - enzymology
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Summary:Summary Considerable research has been conducted on mitochondrial biology as it pertains to aging. However, relatively little attention has been accorded the pyruvate dehydrogenase complex (PDC) relative to how we grow old and acquire age‐related diseases. The purpose of this review is threefold: first, to describe the physiological chemistry of the PDC and define its place in normal cellular bioenergetics; second, to compare and contrast the pathogenesis and clinical features of congenital PDC deficiency with discrete examples of age‐associated dysfunction of the complex; and third, to summarize recent findings in Caenorhabditis elegans that shed additional new light on the significance of the PDC to the aging process.
ISSN:1474-9718
1474-9726
DOI:10.1111/j.1474-9726.2012.00805.x