Definitive chemoradiotherapy in patients with esophageal adenocarcinoma: An alternative to surgery?

Background and Objectives Definitive chemoradiotherapy (CRT) is considered curative intent treatment for locally advanced esophageal squamous cell carcinoma. Data concerning the usefulness of definitive CRT in patients with esophageal adenocarcinoma (ADC) are lacking. The aim of the study was to com...

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Bibliographic Details
Published in:Journal of surgical oncology 2012-06, Vol.105 (8), p.761-766
Main Authors: Tougeron, D., Scotté, M., Hamidou, H., Di Fiore, F., Paillot, B., Michot, F., Michel, P.
Format: Article
Language:English
Subjects:
Adenocarcinoma - mortality
Adenocarcinoma - secondary
Adenocarcinoma - therapy
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cisplatin - administration & dosage
Combined Modality Therapy
definitive chemoradiotherapy
esophageal adenocarcinoma
Esophageal Neoplasms - mortality
Esophageal Neoplasms - pathology
Esophageal Neoplasms - therapy
Female
Fluorouracil - administration & dosage
Follow-Up Studies
Humans
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - therapy
Neoplasm Staging
Prognosis
prognostic factors
Retrospective Studies
surgery
Survival Rate
treatment strategy
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Summary:Background and Objectives Definitive chemoradiotherapy (CRT) is considered curative intent treatment for locally advanced esophageal squamous cell carcinoma. Data concerning the usefulness of definitive CRT in patients with esophageal adenocarcinoma (ADC) are lacking. The aim of the study was to compare the results of definitive CRT versus surgery in patients with an ADC. Methods All consecutive patients with a non‐metastatic ADC treated between 1994 and 2008 were retrospectively assessed. Patients were divided into two groups: surgery group (±pre‐operative treatment) versus definitive CRT group. Results In surgery and definitive CRT groups, 67 and 79 patients were evaluated, respectively. A complete resection was achieved in 92.5% of patients in surgery group and a clinical complete response was observed in 49.4% of patients in definitive CRT group. Overall survival was 36.2 ± 2.0 months in surgery group versus 16.5 ± 0.8 months in definitive CRT group (P = 0.02). The predictive factors of survival were age (P 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.22157