Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity

Numerous lines of evidence indicate that insulin-like growth factor signaling plays an important role in the regulation of life span and tumor development. In the present paper, the role of individual components of insulin-like growth factor signaling in aging and tumor development has been extensiv...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2012-06, Vol.67 (6), p.640-651
Main Authors: Novosyadlyy, Ruslan, Leroith, Derek
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Animals
Cell Transformation, Neoplastic - metabolism
Diabetes Mellitus - metabolism
Female
Forkhead Transcription Factors - metabolism
Humans
Insulin
Insulin - metabolism
Insulin Resistance - physiology
Life expectancy
Longevity - physiology
Male
MAP Kinase Signaling System - physiology
Mice
NF-kappa B - metabolism
Rats
Receptor, Insulin - metabolism
Signal transduction
Somatomedins - metabolism
Tumors
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Summary:Numerous lines of evidence indicate that insulin-like growth factor signaling plays an important role in the regulation of life span and tumor development. In the present paper, the role of individual components of insulin-like growth factor signaling in aging and tumor development has been extensively analyzed. The molecular mechanisms underlying aging and tumor development are frequently overlapping. Although the link between reduced insulin-like growth factor signaling and suppressed tumor growth and development is well established, it remains unclear whether extended life span results from direct suppression of insulin-like growth factor signaling or this effect is caused by indirect mechanisms such as improved insulin sensitivity.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/gls065