ERRs and cancers: Effects on metabolism and on proliferation and migration capacities

ERRs are orphan members of the nuclear receptor superfamily which, at least for ERRα and ERRγ display important roles in the control of various metabolic processes. On other hand, correlations have been found between the expression of ERRα and γ and diverse parameters of tumor progression in human c...

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Bibliographic Details
Published in:The Journal of steroid biochemistry and molecular biology 2012-07, Vol.130 (3-5), p.180-185
Main Authors: Bianco, Stéphanie, Sailland, Juliette, Vanacker, Jean-Marc
Format: Article
Language:English
Subjects:
Animals
Cancer
Cell cycle
Cell Movement
Cell Proliferation
Energy Metabolism
ERR
Humans
Metabolism
Mice
Neoplasms - metabolism
Neoplasms - pathology
Orphan nuclear receptor
Receptors, Estrogen - metabolism
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Summary:ERRs are orphan members of the nuclear receptor superfamily which, at least for ERRα and ERRγ display important roles in the control of various metabolic processes. On other hand, correlations have been found between the expression of ERRα and γ and diverse parameters of tumor progression in human cancers. Whereas it is tempting to speculate that ERR receptors act in tumors through the regulation of metabolism, recent data have suggested that they also may directly regulate tumor proliferation and progression independently of their effects on metabolism. The two aspects of tumoral functions of ERR receptors are the purpose of the present review.
ISSN:0960-0760
1879-1220
DOI:10.1016/j.jsbmb.2011.03.014