Stability of Extemporaneously Prepared 0.5-Percent Caspofungin Eye Drops: a Potential Cost-Savings Exercise

While the successful use of topical caspofungin for patients has been reported, topical caspofungin is not commercially available and its stability is unknown, limiting its usefulness in treating fungal keratitis. Caspofungin (0.5%) eye drops were aseptically prepared, and the concentrations were me...

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Bibliographic Details
Published in:Antimicrobial Agents and Chemotherapy 2012-06, Vol.56 (6), p.3435-3437
Main Authors: Neoh, Chin Fen, Jacob, Jovan, Leung, Lok, Li, Jian, Stathopoulos, Angela, Stewart, Kay, Kong, David C. M
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
antifungal agents
Biological and medical sciences
Chromatography, High Pressure Liquid
Clinical Therapeutics
cost effectiveness
Drug Stability
Drug Storage - economics
Drug Storage - methods
Echinocandins
eyes
fungi
high performance liquid chromatography
keratitis
Lipopeptides
Medical sciences
Ophthalmic Solutions
patients
Pharmacology. Drug treatments
topical application
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Summary:While the successful use of topical caspofungin for patients has been reported, topical caspofungin is not commercially available and its stability is unknown, limiting its usefulness in treating fungal keratitis. Caspofungin (0.5%) eye drops were aseptically prepared, and the concentrations were measured using a validated high-performance liquid chromatography (HPLC) analysis. The preparations remained stable for 28 days under refrigerated condition but not at 25.0°C. Our study supports the cost-saving use of caspofungin eye drops in the clinical setting.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00060-12