Colonisation in adult patients with nosocomial candidemia

Summary The aim of this prospective study was to investigate the association between Candida spp. isolated from blood culture and the colonisation of different anatomical sites of patients with candidemia, and to evaluate the colonisation dynamics and Pittet’s index. Cultures were collected from the...

Full description

Saved in:
Bibliographic Details
Published in:Mycoses 2012-05, Vol.55 (3), p.269-275
Main Authors: Gürcüoğlu, Emel, Akalın, Halis, Ener, Beyza, Gedikoğlu, Suna
Format: Article
Language:English
Subjects:
Adult
Aged
Blood culture
Candida
Candida - classification
Candida - genetics
Candida - isolation & purification
Candida colonisation
Candidemia
Candidemia - microbiology
Candidemia - pathology
Cross Infection - microbiology
Cross Infection - pathology
Female
Hospitals
Humans
Male
Middle Aged
nosocomial fungal infections
Prospective Studies
Rectum
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary The aim of this prospective study was to investigate the association between Candida spp. isolated from blood culture and the colonisation of different anatomical sites of patients with candidemia, and to evaluate the colonisation dynamics and Pittet’s index. Cultures were collected from the different anatomical sites of all the patients within 24 h of diagnosis of candidemia. Molecular similarities between identical species colonised with Candida species were evaluated via karyotyping. The colonisation index, as developed by Pittet et al. was calculated using screening culture results from patients. Among the 40 patients screened for colonisation, 35 (87.5%) had colonisation of at least one anatomical site. Twenty‐six (74.3%) of the 35 patients with colonisation in any of the three anatomical sites (respiratory, rectum and urinary sites) were shown to be colonised with the same species that caused candidemia. When the anatomical sites were compared with each other, no significant difference was observed at the species level in terms of colonisation index. The colonisation index (≥0.5) positivity rate was 74% in patients with candidemia. The investigation of Candida colonisation of at least three anatomical (respiratory, rectum and urinary) sites could help in the selection of empirical antifungal therapy when nosocomial candidemia is suspected.
ISSN:0933-7407
1439-0507
DOI:10.1111/j.1439-0507.2011.02083.x