Tau protein: a possible prognostic factor in optic neuritis and multiple sclerosis

• Published in: Multiple sclerosis 2012-05, Vol.18 (5), p.592-599
• Main Authors: Frederiksen, J, Kristensen, K, Bahl, JMC, Christiansen, M
• Format: Article
• Language: English
• Subjects: 14-3-3 protein; 14-3-3 Proteins - cerebrospinal fluid; Adult; Biological and medical sciences; biomarkers; Biomarkers - cerebrospinal fluid; Brain - metabolism; Cerebrospinal fluid; Data processing; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Denmark; Disability Evaluation; Disease Progression; Female; Hospitals; Hospitals, University; Humans; Male; Medical sciences; Middle Aged; Multiple sclerosis; Multiple Sclerosis - cerebrospinal fluid; Multiple Sclerosis - diagnosis; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurological complications; Neurology; Optic neuritis; Optic Neuritis - cerebrospinal fluid; Optic Neuritis - diagnosis; Prognosis; Severity of Illness Index; Tau protein; tau Proteins - cerebrospinal fluid; Time Factors; Up-Regulation; Young Adult
• ISSN: 1352-4585; 1477-0970
• DOI: 10.1177/1352458511424588

Background: Tau protein has been proposed as biomarker of axonal damage leading to irreversible neurological impairment in MS. CSF concentrations may be useful when determining risk of progression from ON to MS. Objective: To investigate the association between tau protein concentration and 14-3-3 protein in the cerebrospinal fluid (CSF) of patients with monosymptomatic optic neuritis (ON) versus patients with monosymptomatic onset who progressed to multiple sclerosis (MS). To evaluate results against data found in a complete literature review. Methods: A total of 66 patients with MS and/or ON from the Department of Neurology of Glostrup Hospital, University of Copenhagen, Denmark, were included. CSF samples were analysed for tau protein and 14-3-3 protein, and clinical and paraclinical information was obtained from medical records. Results: The study shows a significantly increased concentration of tau protein in CSF from patients with relapsing–remitting MS and patients monosymptomatic at onset who progressed to MS, but interestingly no increased tau protein concentration in monosymptomatic ON. The concentration of tau protein was significantly correlated to Expanded Disability Status Scale score. No 14-3-3 protein was detected in any CSF sample. Conclusions: The results of this study invite further exploration of the possible role of tau protein as a prognostic factor to predict progression from ON to MS in future studies.