Increase in Sensorimotor Cortex Response to Somatosensory Stimulation Over Subacute Poststroke Period Correlates With Motor Recovery in Hemiparetic Patients

Background. Somatosensory input to the motor cortex may play a critical role in motor relearning after hemiparetic stroke. Objective. The authors tested the hypothesis that motor recovery after hemiparetic stroke relates to changes in responsiveness of the sensorimotor cortex (SMC) to somatosensory...

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Bibliographic Details
Published in:Neurorehabilitation and neural repair 2012-05, Vol.26 (4), p.325-334
Main Authors: Schaechter, Judith D., van Oers, Casper A. M. M., Groisser, Benjamin N., Salles, Sara S., Vangel, Mark G., Moore, Christopher I., Dijkhuizen, Rick M.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cortex (motor)
Cortex (somatosensory)
Female
Follow-Up Studies
Functional Laterality - physiology
Functional magnetic resonance imaging
Hand Strength - physiology
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Motor Skills - physiology
Neurology
Oxygen - blood
Paresis - etiology
Paresis - rehabilitation
Physical Therapy Modalities
Recovery of Function - physiology
Rehabilitation
Relearning
sensorimotor system
Somatosensory Cortex - blood supply
Somatosensory Cortex - physiology
Stroke
Stroke - complications
Stroke Rehabilitation
Tactile stimuli
Time Factors
Young Adult
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Summary:Background. Somatosensory input to the motor cortex may play a critical role in motor relearning after hemiparetic stroke. Objective. The authors tested the hypothesis that motor recovery after hemiparetic stroke relates to changes in responsiveness of the sensorimotor cortex (SMC) to somatosensory input. Methods. A total of 10 hemiparetic stroke patients underwent serial functional magnetic resonance imaging (fMRI) during tactile stimulation and testing of sensorimotor function over 1 year—at early subacute, late subacute, and chronic poststroke time points. Results. Over the subacute poststroke period, increased responsiveness of the ipsilesional SMC to tactile stimulation of a stroke-affected digit correlated strongly with concurrent gains in motor function. Increased responsiveness of the ipsilesional and contralesional SMC over the subacute period also correlated strongly with motor recovery experienced over the first year poststroke. Conclusions. These findings suggest that increased responsiveness of the SMC to somatosensory stimulation over the subacute poststroke period may contribute to motor recovery.
ISSN:1545-9683
1552-6844
DOI:10.1177/1545968311421613