Overexpression of nuclear NHERF1 in advanced colorectal cancer: Association with hypoxic microenvironment and tumor invasive phenotype

Over 57% of colorectal cancer (CRC) patients have regional or distant spread of their disease at the time of diagnosis. Despite recent advances, there is a compelling need to better characterize prognostic markers for advanced CRC. The present study investigates protein expression of NHERF1, HIF-1α...

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Bibliographic Details
Published in:Experimental and molecular pathology 2012-06, Vol.92 (3), p.296-303
Main Authors: Malfettone, Andrea, Silvestris, Nicola, Paradiso, Angelo, Mattioli, Eliseo, Simone, Giovanni, Mangia, Annita
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - biosynthesis
Colorectal cancer
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Female
Fluorescent Antibody Technique
Gastroenterology. Liver. Pancreas. Abdomen
HIF-1α
Humans
Hypoxia
Hypoxia - metabolism
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Linear Models
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
NHERF1
Nuclear Proteins - metabolism
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Phosphoproteins - biosynthesis
Retrospective Studies
Sodium-Hydrogen Exchangers - biosynthesis
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumor marker
Tumor Microenvironment
Tumors
TWIST
Twist-Related Protein 1 - metabolism
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Summary:Over 57% of colorectal cancer (CRC) patients have regional or distant spread of their disease at the time of diagnosis. Despite recent advances, there is a compelling need to better characterize prognostic markers for advanced CRC. The present study investigates protein expression of NHERF1, HIF-1α and TWIST1 and their relationship in distant normal mucosa (DNM), tumor (T) and adjacent normal mucosa (ANM), lymph node metastasis (LNM) and liver metastasis (LM), determining their role as potential markers in advanced stages of human CRC. Overexpression of nuclear NHERF1 was shown in 47% of tumors, which exhibited a significant association with poor histological grade (P=0.0346). Nuclear NHERF1 showed a higher expression in T, LNM and LM than both DNM (P
ISSN:0014-4800
1096-0945
DOI:10.1016/j.yexmp.2012.03.004