The Acute Effects of Passive Smoking on Mean Platelet Volume in Healthy Volunteers

• Published in: Angiology 2012-07, Vol.63 (5), p.353-357
• Main Authors: Yarlioglues, Mikail, Ardic, Idris, Dogdu, Orhan, Akpek, Mahmut, Zencir, Cemil, Kasapkara, Haci Ahmet, Kelesoglu, Saban, Elcik, Deniz, Ozdogru, Ibrahim, Oguzhan, Abdurrahman, Kaya, Mehmet Gungor
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Blood and lymphatic vessels; Blood coagulation. Blood cells; Blood Platelets - drug effects; Blood Platelets - pathology; Carbon Monoxide - adverse effects; Cardiology. Vascular system; Cell Size - drug effects; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Dose-Response Relationship, Drug; Female; Fundamental and applied biological sciences. Psychology; Humans; Male; Medical sciences; Molecular and cellular biology; Platelet; Platelet Activation - drug effects; Platelet Count; Prospective Studies; Smoke - adverse effects; Time Factors; Tobacco Smoke Pollution - adverse effects; Turkey; Young Adult
• ISSN: 0003-3197; 1940-1574
• DOI: 10.1177/0003319711420131

Mean platelet volume (MPV) is an indicator of platelet activation. We investigated the acute effect of passive smoking on MPV in healthy volunteers. Healthy nonsmoker volunteers (n = 90) spent 120 minutes in a smoke-free room. Then they were exposed to passive smoking in 3 groups consisting of 30 volunteers each in group A (carbon monoxide [CO] 15 ppm) for 120 minutes in a smoking room. Mean platelet volume did not change in group A and in the smoke-free room. Mean platelet volume increased significantly at the 60th minute and continued to increase at the 90th and 120th minute in group B. Mean platelet volume increased significantly at the 30th minute and continued to increase at the 60th, 90th, and 120th minute in group C. In conclusion, acute exposure to passive smoking affected MPV according to the duration and intensity of smoke.