In Vivo Antihyperlipidemic Activity of a New Series of N-(Benzoylphenyl) and N-(Acetylphenyl)-1-benzofuran-2-carboxamides in Rats

A new series of N‐(benzoylphenyl) and N‐(acetylphenyl)‐1‐benzofuran‐2‐carboxamides (3a–3d and 4a′–4c′) were synthesized. Compounds (3a, 3b, and 4a′–4c′) were tested in vivo using Triton‐WR‐1339‐induced hyperlipidemic rats as an experimental model for their hypolipidemic activity. The tested animals...

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Bibliographic Details
Published in:Archiv der Pharmazie (Weinheim) 2012-05, Vol.345 (5), p.401-406
Main Authors: Al-Qirim, Tariq, Shattat, Ghassan, Sweidan, Kamal, El-Huneidi, Waseem, Sheikha, Ghassan Abu, Khalaf, Reema Abu, Hikmat, Suhair
Format: Article
Language:English
Subjects:
Animals
Benzofurans - chemical synthesis
Benzofurans - pharmacology
Bezafibrate - pharmacology
Cholesterol
Cholesterol, HDL - blood
Cholesterol, LDL - blood
High-density lipoprotein-cholesterol
Hypolipidemic activity
Hypolipidemic Agents - chemical synthesis
Hypolipidemic Agents - pharmacology
Male
Medical research
N-(Benzoylphenyl) and N-(acetylphenyl)-1-benzofuran-2-carboxamides
Polyethylene Glycols
Rats
Rats, Wistar
Structure-Activity Relationship
Triglycerides
Triglycerides - blood
Triton-induced hyperlipidemia
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Summary:A new series of N‐(benzoylphenyl) and N‐(acetylphenyl)‐1‐benzofuran‐2‐carboxamides (3a–3d and 4a′–4c′) were synthesized. Compounds (3a, 3b, and 4a′–4c′) were tested in vivo using Triton‐WR‐1339‐induced hyperlipidemic rats as an experimental model for their hypolipidemic activity. The tested animals were divided into eight groups: control, hyperlipidemic, 3a, 3b, 4a′, 4b′, 4c′, and bezafibrate. At a dose of 15 mg/kg, the elevated plasma triglyceride (TG) levels were significantly reduced in compounds 3b (p 
ISSN:0365-6233
1521-4184
DOI:10.1002/ardp.201100225