A highly sensitive, multiplex immunoassay using gold nanoparticle-enhanced signal amplification

We describe a highly sensitive, multiplex immunoassay utilizing gold nanoparticles for conjugation of detection antibodies with signal generators. The method has been compared with conventional methods and evaluated for simultaneous detection of two different biomarkers in human serum.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-06, Vol.48 (47), p.5895-5897
Main Authors: Han, Ki-Cheol, Yang, Eun Gyeong, Ahn, Dae-Ro
Format: Article
Language:English
Subjects:
alpha-Fetoproteins - analysis
Antibodies - chemistry
Biomarkers - blood
DNA - chemistry
Fatty Acid-Binding Proteins - blood
Gold - chemistry
Humans
Immunoassay - methods
Metal Nanoparticles - chemistry
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Description
Summary:We describe a highly sensitive, multiplex immunoassay utilizing gold nanoparticles for conjugation of detection antibodies with signal generators. The method has been compared with conventional methods and evaluated for simultaneous detection of two different biomarkers in human serum.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc31659e