Improved oral bioavailability of alendronate via the mucoadhesive liposomal delivery system

This study aimed to design the chitosan coated liposomes of alendronate and optimize their in vitro/in vivo characteristics to improve the bioavailability as well as potentially to reduce the mucosal irritation of alendronate. Liposomes of alendronate were prepared with DSPC/DSPG by using thin layer...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmaceutical sciences 2012-08, Vol.46 (5), p.500-507
Main Authors: Han, Hyo-Kyung, Shin, Hyun-Jae, Ha, Dong Hoon
Format: Article
Language:English
Subjects:
Adhesiveness
Administration, Oral
Alendronate
Alendronate - administration & dosage
Alendronate - chemistry
Alendronate - pharmacokinetics
Animals
Bioavailability
Biological and medical sciences
Biological Availability
Bone Density Conservation Agents - administration & dosage
Bone Density Conservation Agents - chemistry
Bone Density Conservation Agents - pharmacokinetics
Caco-2 Cells
Chemistry, Pharmaceutical
Chitosan - chemistry
Chitosan - metabolism
Drug Stability
General pharmacology
Humans
Intestinal Absorption
Intestinal Mucosa - metabolism
Lipids - chemistry
Liposome
Liposomes
Male
Medical sciences
Mucins - metabolism
Mucoadhesive
Nanoparticles
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Phosphatidylcholines - chemistry
Rat
Rats
Rats, Sprague-Dawley
Technology, Pharmaceutical - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to design the chitosan coated liposomes of alendronate and optimize their in vitro/in vivo characteristics to improve the bioavailability as well as potentially to reduce the mucosal irritation of alendronate. Liposomes of alendronate were prepared with DSPC/DSPG by using thin layer film hydration method and then the surface of anionic liposomes was coated by chitosan. In vitro characteristics of liposomes (e.g., stability in various biological media, mucoadhesiveness and cellular uptake profiles) were evaluated along with the pharmacokinetic studies in rats. Lipid vesicles of 200nm size were obtained with narrow size distribution (PI
ISSN:0928-0987
1879-0720
DOI:10.1016/j.ejps.2012.04.002