Improvement of the (99m)Tc-ECD brain uptake ratio (BUR) method for measurement of cerebral blood flow

The brain uptake ratio (BUR) method for the (99m)Tc-ECD SPECT, a non-invasive measurement method of rCBF, has been used in clinical practice in Japan, because it is simple to use. However, the accuracy of this method is limited, as it has problems in the determination of input function and the regre...

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Bibliographic Details
Published in:Annals of nuclear medicine 2012-05, Vol.26 (4), p.351-358
Main Authors: Ito, Shigeki, Takaki, Akihiro, Inoue, Shinya, Tomiguchi, Seiji, Shiraishi, Shinya, Akiyama, Yasuhiko, Sasaki, Toshiaki, Odajima, Satoshi, Teraoka, Satomi, Hosoya, Tetsuo, Soma, Tsutomu, Miyazaki, Yoshiharu, Kinuya, Seigo, Yamashita, Yasuyuki
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Area Under Curve
Biological Transport
Brain - blood supply
Brain - diagnostic imaging
Brain - metabolism
Cerebrovascular Circulation
Cysteine - analogs & derivatives
Cysteine - metabolism
Female
Humans
Male
Middle Aged
Organotechnetium Compounds - metabolism
Oxygen Radioisotopes
Positron-Emission Tomography
Regression Analysis
Retrospective Studies
Tomography, Emission-Computed, Single-Photon
Water
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Summary:The brain uptake ratio (BUR) method for the (99m)Tc-ECD SPECT, a non-invasive measurement method of rCBF, has been used in clinical practice in Japan, because it is simple to use. However, the accuracy of this method is limited, as it has problems in the determination of input function and the regression equation. The purpose of this study is to improve the BUR method by reconstructing the determination process of the input function and regression equation based on measurement of the rCBF by H (2) (15) O PET. The input function was obtained by setting the region of interest on the ascending aorta instead of the aortic arch. The 3DSRT algorithm was used to obtain the anatomically standardized rCBF, and developed a semi-automatic analyzing software using C++ in order to stabilize the repeatability of the improved BUR (IBUR) method. The regression equation for the IBUR method was obtained by the H (2) (15) O PET rCBFs in 15 patients with the arterial blood sampling method. All the measurements in this study were performed with the patient in the resting state. A good correlation was observed between the rCBF values measured by H (2) (15) O PET and the regional BURs measured by the IBUR method (r = 0.86, p 
ISSN:1864-6433
DOI:10.1007/s12149-012-0582-7