Detection of KPC-2 and qnrS1 in clinical isolates of Morganella morganii from China

Abstract Seven carbapenem-nonsusceptible Morganella morganii isolates, which have similar antibiotic susceptibility profiles, were isolated over a 5-month period. MICs of imipenem, meropenem, and ertapenem were 8, 1, and 0.25 to 0.5 μg/mL, respectively. Pulsed-field gel electrophoresis indicated tha...

Full description

Saved in:
Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2012-06, Vol.73 (2), p.207-209
Main Authors: Cai, Jia Chang, Yang, Wei, Hu, Yan Yan, Zhang, Rong, Zhou, Hong Wei, Chen, Gong-Xiang
Format: Article
Language:English
Subjects:
Aged
Amide Synthases - analysis
Amide Synthases - biosynthesis
Amide Synthases - genetics
Anti-Bacterial Agents - pharmacology
Antimicrobial resistance
Bacterial Proteins - genetics
Bacteriology
beta-Lactamases - analysis
beta-Lactamases - biosynthesis
beta-Lactamases - genetics
Biological and medical sciences
Carbapenems
China
Drug Resistance, Bacterial
Enterobacteriaceae
Enterobacteriaceae Infections - microbiology
Fundamental and applied biological sciences. Psychology
Humans
Infectious Disease
Infectious diseases
Internal Medicine
Medical sciences
Microbial Sensitivity Tests
Microbiology
Miscellaneous
Molecular Epidemiology
Morganella morganii - drug effects
Morganella morganii - genetics
Morganella morganii - isolation & purification
Morganella morganii - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Seven carbapenem-nonsusceptible Morganella morganii isolates, which have similar antibiotic susceptibility profiles, were isolated over a 5-month period. MICs of imipenem, meropenem, and ertapenem were 8, 1, and 0.25 to 0.5 μg/mL, respectively. Pulsed-field gel electrophoresis indicated that 6 isolates were indistinguishable or closely related. Carbapenem resistance can be transferred from M. morganii to Escherichia coli by conjugation. All M. morganii isolates and E. coli transconjugants produced KPC-2 and carried the qnrS1 gene. Production of KPC-2 mainly contributed to the carbapenem resistance in M. morganii . KPC-2–producing M. morganii clonally spread in a hospital in China.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2012.03.013