Relationship Between Choroidal Thickness and Choroidal Circulation in Healthy Young Subjects

Purpose To investigate the relationship between the choroidal thickness and choroidal blood flow in healthy young subjects. Design Retrospective, cross-sectional study. Methods We examined 25 eyes of 25 healthy young Japanese subjects. The subfoveal choroidal thickness was measured by enhanced depth...

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Bibliographic Details
Published in:American journal of ophthalmology 2012-06, Vol.153 (6), p.1129-1132.e1
Main Authors: Sogawa, Kenji, Nagaoka, Taiji, Takahashi, Atsushi, Tanano, Ichiro, Tani, Tomofumi, Ishibazawa, Akihiro, Yoshida, Akitoshi
Format: Article
Language:English
Subjects:
Adult
Axial Length, Eye
Biological and medical sciences
Blood Flow Velocity - physiology
Choroid - anatomy & histology
Choroid - blood supply
Cross-Sectional Studies
Disease
Eyes & eyesight
Female
Humans
Intraocular Pressure - physiology
Laser-Doppler Flowmetry
Lasers
Life sciences
Macular degeneration
Male
Manometry
Medical imaging
Medical sciences
Miscellaneous
Myopia
Ophthalmology
Regional Blood Flow - physiology
Retrospective Studies
Studies
Tomography, Optical Coherence
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Summary:Purpose To investigate the relationship between the choroidal thickness and choroidal blood flow in healthy young subjects. Design Retrospective, cross-sectional study. Methods We examined 25 eyes of 25 healthy young Japanese subjects. The subfoveal choroidal thickness was measured by enhanced depth imaging optical coherence tomography (EDI-OCT). The total choroidal blood flow and subfoveal choroidal blood flow were evaluated by pulsatile ocular blood flow using Langham OBF computerized tonometry and the choroidal blood flow using laser Doppler flowmetry. The refractive error, intraocular pressure, and axial length were also measured. Results The mean refractive error was −3.4 ± 3.1 diopters, mean intraocular pressure 15.3 ± 1.7 mm Hg, and axial length 25.4 ± 2.0 mm. The subfoveal choroidal thickness was correlated positively (r = 0.785, P < .01) with the refractive error and negatively (r = −0.735, P < .001) with the axial length. No significant correlation was found between the subfoveal choroidal thickness and the pulsatile ocular blood flow or choroidal blood flow. Conclusion Our results suggested that there were no significant correlations between the subfoveal choroidal thickness and the total choroidal blood flow and the subfoveal choroidal blood flow in healthy young subjects; however, decreased subfoveal choroidal thickness was associated with decreased refractive error and axial length.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2011.11.005