Clinical characteristics and risk factors of ocular candidiasis

Abstract Ocular candidiasis is a major complication of Candida bloodstream infection (BSI). This study was performed to reveal the clinical characteristics of ocular candidiasis. Of the 220 patients with Candida BSI, 204 cases received ophthalmology consultations between January 2005 and December 20...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2012-06, Vol.73 (2), p.149-152
Main Authors: Nagao, Miki, Saito, Takashi, Doi, Shoichi, Hotta, Gou, Yamamoto, Masaki, Matsumura, Yasufumi, Matsushima, Aki, Ito, Yutaka, Takakura, Shunji, Ichiyama, Satoshi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
beta-Glucans - metabolism
Biological and medical sciences
Candidemia
Candidemia - epidemiology
Candidemia - pathology
Candidiasis - epidemiology
Candidiasis - pathology
Diagnostic Techniques, Ophthalmological
Eye Infections, Fungal - diagnosis
Eye Infections, Fungal - epidemiology
Eye Infections, Fungal - microbiology
Eye Infections, Fungal - pathology
Female
Fundamental and applied biological sciences. Psychology
Fundoscopic investigation
Humans
Incidence
Infectious Disease
Infectious diseases
Internal Medicine
Male
Medical sciences
Microbiology
Middle Aged
Miscellaneous
Multivariate Analysis
Mycology
Ocular candidiasis
Odds Ratio
Risk Factors
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Summary:Abstract Ocular candidiasis is a major complication of Candida bloodstream infection (BSI). This study was performed to reveal the clinical characteristics of ocular candidiasis. Of the 220 patients with Candida BSI, 204 cases received ophthalmology consultations between January 2005 and December 2011 at 2 teaching hospitals. Fifty-four (26.5%) cases had findings consistent with the diagnosis of ocular candidiasis. Of these 54 cases, 43 (79.6%) were diagnosed within 7 days after a positive blood culture. Among ocular candidiasis cases, more cases were due to Candida albicans ( P =0.034 odds ratio [OR]; 3.68 95% confidence interval [CI] 1.11–12.2) and had higher β- d -glucan values ( P = 0.001 OR; 9.99 95% CI 2.60–21.3). We need to consider fundoscopic examination to be performed within the first 7 days of therapy, especially for those patients who have C. albicans BSIs and higher β- d -glucan values. Additionally, follow-up fundoscopic examination should be considered before stopping therapy for high-risk patients.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2012.03.006