Transcutaneous bilirubin measurement: Comparison of Respironics BiliCheck and JM-103 in a normal newborn population

• Published in: Clinical biochemistry 2012-06, Vol.45 (9), p.659-662
• Main Authors: Romagnoli, Costantino, Zecca, Enrico, Catenazzi, Piero, Barone, Giovanni, Zuppa, Antonio Alberto
• Format: Article
• Language: English
• Subjects: Bilirubin - blood; Biological and medical sciences; Birth Weight; Double-Blind Method; Female; Gestational Age; Humans; Hyperbilirubinemia - blood; Hyperbilirubinemia - diagnosis; Infant, Newborn; Investigative techniques, diagnostic techniques (general aspects); Jaundice; Jaundice, Neonatal - blood; Jaundice, Neonatal - diagnosis; Light; Male; Medical sciences; Neonatal Screening; Neonate; Optical Devices; Prospective Studies; Regression Analysis; ROC Curve; Skin - blood supply; Skin - metabolism; Transcutaneous bilirubin measurement
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/j.clinbiochem.2012.03.014

To compare the accuracy of BiliCheck™ (Respironics, Marietta, GA) and Konica-Minolta Air Shield JM-103 (Drager Medical Inc, Telford, PA) to evaluate total serum bilirubin (TSB). Prospective blinded study comparing two diagnostic devices in 630 neonates requiring TSB measurement. Linear regression analysis showed a good correlation between BiliCheck™ and TSB (r=0.8212) as well as between JM-103 and TSB (r=0.8686). BiliCheck shows a tendency to underestimate TSB. The mean difference in TSB–TcB was −1.4mg/dL for BC (−4.7/+1.8mg/dL) and 0.3mg/dL for JM-103 (−2.6/+3.2mg/dL). ROC analysis for TSB≥12mg/dL showed area under the curve for BiliCheck™ significantly lower than those for JM-103 (p