RECIPROCAL CHROMOSOME TRANSLOCATIONS IN 437 COUPLES WITH REPRODUCTIVE DISORDERS

Chromosomal abnormalities are the major contributors to genetic causes of reproductive disorders. The aim of this study was to determine the occurence of reciprocal chromosome translocations in couples with reproductive disorder from the Prešov region (Slovakia) in 1998–2010. We analyzed the karyoty...

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Bibliographic Details
Published in:Anthropologie (Brno) 2010-01, Vol.48 (2), p.195-198
Main Authors: BOROŇOVÁ, IVETA, BERNASOVSKÝ, IVAN, BERNASOVSKÁ, JARMILA, BEHULOVÁ, REGÍNA, PETREJČÍKOVÁ, EVA, BÔŽIKOVÁ, ALEXANDRA, GABRIKOVÁ, DANA, MAČEKOVÁ, SOŇA, SOTÁK, MIROSLAV, SOVIČOVÁ, ADRIANA, SIKOROVÁ, LUCIA
Format: Article
Language:English
Subjects:
Chromosome aberrations
Chromosome disorders
Chromosome translocation
Chromosomes
Cytogenetics
Etiology
Genetic counseling
Genetics
Health
Infertility
Medical anthropology
Meiosis
Men
ORIGINAL PAPERS • TRAVAUX ORIGINAUX • ORIGINALARBEITEN
Reciprocal translocation
Reproductive health
Sex chromosomes
Slovakia
Spontaneous abortion
Women
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Summary:Chromosomal abnormalities are the major contributors to genetic causes of reproductive disorders. The aim of this study was to determine the occurence of reciprocal chromosome translocations in couples with reproductive disorder from the Prešov region (Slovakia) in 1998–2010. We analyzed the karyotypes of 437 couples with clinical diagnosis of reproductive disorder including infertility, recurrent fetal loss, congenital anomalies in the offsprings and sterility. The karyotypes were determined using cytogenetic banding techniques (GTG-banded metaphases). Routine cytogenetic analyses involved a total of 48 aberrant karyotypes corresponding to an abnormality frequency of 5.5%. Reciprocal chromosome translocations were found in six couples (1.4%), four female (0.9%) and two male (0.5%) partners. The identification of chromosomal abnormalities as the etiology facilitated the counseling and appropriate management.
ISSN:0323-1119
2570-9127