Adipocytokines and Insulin Resistance across Various Degrees of Glucose Tolerance in Pregnancy

OBJECTIVE: Gestational diabetes mellitus is characterized by progressive insulin resistance. Adipocytokines are thought to be associated with insulin resistance. This cross-sectional study evaluated the associations between serum concentrations of several adipocytokines and insulin resistance at dif...

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Bibliographic Details
Published in:Journal of international medical research 2012-04, Vol.40 (2), p.583-589
Main Authors: Skvarca, A, Tomazic, M, Krhin, B, Blagus, R, Janez, A
Format: Article
Language:English
Subjects:
Adipokines - blood
Adiponectin - blood
Adult
Blood Glucose - analysis
Cross-Sectional Studies
Diabetes, Gestational - blood
Diabetes, Gestational - etiology
Female
Glucose - metabolism
Glucose Clamp Technique
Humans
Insulin - blood
Insulin - metabolism
Insulin Resistance
Leptin - blood
Nicotinamide Phosphoribosyltransferase - blood
Pregnancy
Resistin - blood
Retinol-Binding Proteins, Plasma - analysis
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Summary:OBJECTIVE: Gestational diabetes mellitus is characterized by progressive insulin resistance. Adipocytokines are thought to be associated with insulin resistance. This cross-sectional study evaluated the associations between serum concentrations of several adipocytokines and insulin resistance at different stages of glucose tolerance in pregnancy, using the homeostasis model assessment of insulin resistance (HOMA-IR) as a reference. METHODS: According to oral glucose tolerance test results, 74 pregnant women were divided into three groups: normal glucose tolerance (n = 25); intermediate glucose tolerance (n = 19); gestational diabetes mellitus (n = 30). Adiponectin, leptin, resistin, visfatin and retinol-binding protein 4 (RBP4) concentrations were measured using enzyme-linked immunosorbent assays. RESULTS: Groups were comparable regarding age, week of gestation and body mass index before gestation. There were statistically significant between-group differences in HOMA-IR, but no significant differences regarding serum adipocytokine concentrations. CONCLUSIONS: Adiponectin, leptin, resistin, visfatin and RBP4 were not associated with the degree of glucose tolerance in pregnancy. Concentrations of these adipocytokines are not sufficiently sensitive to replace HOMA-IR in pregnancy.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323001204000220