Papillary thyroid carcinomas with and without BRAF  V600E mutations are morphologically distinct

Finkelstein A, Levy G H, Hui P, Prasad A, Virk R, Chhieng D C, Carling T, Roman S A, Sosa J A, Udelsman R, Theoharis C G & Prasad M L 
(2012) Histopathology 60, 1052–1059 Papillary thyroid carcinomas with and without BRAF V600E mutations are morphologically distinct Aims:  The BRAF V600E mutatio...

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Published in:Histopathology 2012-06, Vol.60 (7), p.1052-1059
Main Authors: Finkelstein, Alexander, Levy, Gillian H, Hui, Pei, Prasad, Avinash, Virk, Renu, Chhieng, David C, Carling, Tobias, Roman, Sanziana A, Sosa, Julie A, Udelsman, Robert, Theoharis, Constantine G, Prasad, Manju L
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Amino Acid Substitution
Base Sequence
Biological and medical sciences
BRAF mutation
Carcinoma
Carcinoma, Papillary - genetics
Carcinoma, Papillary - pathology
Child
DNA Mutational Analysis
DNA Primers
Endocrinopathies
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Malignant tumors
Medical sciences
Middle Aged
molecular testing
Mutant Proteins - genetics
Mutation, Missense
Non tumoral diseases. Target tissue resistance. Benign neoplasms
papillary
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Point Mutation
Proto-Oncogene Proteins B-raf - genetics
thyroid
Thyroid Cancer, Papillary
thyroid carcinoma
Thyroid Neoplasms - genetics
Thyroid Neoplasms - pathology
Thyroid. Thyroid axis (diseases)
Young Adult
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Summary:Finkelstein A, Levy G H, Hui P, Prasad A, Virk R, Chhieng D C, Carling T, Roman S A, Sosa J A, Udelsman R, Theoharis C G & Prasad M L 
(2012) Histopathology 60, 1052–1059 Papillary thyroid carcinomas with and without BRAF V600E mutations are morphologically distinct Aims:  The BRAF V600E mutation resulting in the production of an abnormal BRAF protein has emerged as the most frequent genetic alteration in papillary thyroid carcinomas (PTCs). This study was aimed at identifying distinctive features in tumours with and without the mutation. Methods and results:  Thirty‐four mutation‐positive and 22 mutation‐negative tumours were identified by single‐strand conformation polymorphism of the amplified BRAF V600E region in the tumour DNA. Mutation‐positive tumours were more common in patients older than 45 years (24/33, P = 0.05), in classic (23/30, P = 0.01), tall cell (4/5) and oncocytic/Warthin‐like (2/2) variants of PTC, and in subcapsular sclerosing microcarcinomas (4/4). In contrast, all 12 follicular variants (P 
ISSN:0309-0167
1365-2559
DOI:10.1111/j.1365-2559.2011.04149.x