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Vitamin D 25-hydroxylase – Four decades of searching, are we there yet?

Bioactivation of vitamin D3 involves 25-hydroxylation and subsequent 1α-hydroxylation to produce 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active hormone. Six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed...

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Bibliographic Details
Published in:Archives of biochemistry and biophysics 2012-07, Vol.523 (1), p.30-36
Main Authors: Zhu, Jinge, DeLuca, Hector F.
Format: Article
Language:English
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Summary:Bioactivation of vitamin D3 involves 25-hydroxylation and subsequent 1α-hydroxylation to produce 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active hormone. Six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed, and their physiological relevance as vitamin D 25-hydroxylases in vivo is discussed.
ISSN:0003-9861
1096-0384
DOI:10.1016/j.abb.2012.01.013