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Vitamin D 25-hydroxylase – Four decades of searching, are we there yet?
Bioactivation of vitamin D3 involves 25-hydroxylation and subsequent 1α-hydroxylation to produce 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active hormone. Six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed...
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Published in: | Archives of biochemistry and biophysics 2012-07, Vol.523 (1), p.30-36 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Bioactivation of vitamin D3 involves 25-hydroxylation and subsequent 1α-hydroxylation to produce 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active hormone. Six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed, and their physiological relevance as vitamin D 25-hydroxylases in vivo is discussed. |
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ISSN: | 0003-9861 1096-0384 |
DOI: | 10.1016/j.abb.2012.01.013 |