Detection of subclinical atherosclerosis in familial hypercholesterolemia using non-invasive imaging modalities

Highlights ► Despite treatment FH patients have higher atherosclerotic burden than controls. ► Aortic MRI allows to characterize atherosclerotic plaques in FH patients. ► In FH patients there is a correlation between aortic wall volume and cIMT. ► Lipid plaques in FH were associated with coronary ar...

Full description

Saved in:
Bibliographic Details
Published in:Atherosclerosis 2012-06, Vol.222 (2), p.468-472
Main Authors: Caballero, Paloma, Alonso, Rodrigo, Rosado, Paloma, Mata, Nelva, Fernández-Friera, Leticia, Jiménez-Borreguero, Luis Jesús, Badimon, Lina, Mata, Pedro
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Aorta
Aorta, Thoracic - pathology
Aortic Diseases - diagnosis
Aortic Diseases - etiology
Aortic Diseases - pathology
Asymptomatic Diseases
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - diagnosis
Atherosclerosis - diagnostic imaging
Atherosclerosis - etiology
Atherosclerosis - pathology
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiovascular
Cardiovascular system
Carotid Artery Diseases - diagnosis
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - etiology
Carotid Artery, Common - diagnostic imaging
Carotid Intima-Media Thickness
Case-Control Studies
Chi-Square Distribution
coronary artery disease
Coronary Artery Disease - etiology
Cross-Sectional Studies
Familial Hypercholesterolemia
Female
Humans
hypercholesterolemia
Hyperlipoproteinemia Type II - complications
Hyperlipoproteinemia Type II - drug therapy
Hyperlipoproteinemia Type II - genetics
Hypolipidemic Agents - therapeutic use
image analysis
Investigative techniques, diagnostic techniques (general aspects)
Linear Models
Magnetic Resonance Angiography
magnetic resonance imaging
Male
males
Medical sciences
Middle Aged
middle-aged adults
MRI
Multivariate Analysis
patients
Plaque, Atherosclerotic
Predictive Value of Tests
Radionuclide investigations
Risk Assessment
Risk Factors
Spain
ultrasonics
Ultrasound
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► Despite treatment FH patients have higher atherosclerotic burden than controls. ► Aortic MRI allows to characterize atherosclerotic plaques in FH patients. ► In FH patients there is a correlation between aortic wall volume and cIMT. ► Lipid plaques in FH were associated with coronary artery disease in relatives.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2012.02.043