Evaluation of possible subclinical atherosclerosis in adolescents with a family history of premature atherosclerosis

Highlights ► We aimed to evaluate the adolescents who are at high risk of premature atherosclerosis. ► Thirty-three subjects who have a father with a history of obstructive coronary artery disease before the age 40 and 30 controls were enrolled to the study. ► Carotid intima-media thickness and puls...

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Bibliographic Details
Published in:Atherosclerosis 2012-06, Vol.222 (2), p.537-540
Main Authors: Celik, Atac, Ozcetin, Mustafa, Celikyay, Zekiye Ruken Yuksekkaya, Sogut, Erkan, Yerli, Yasemin, Kadi, Hasan, Koc, Fatih, Damar, Ibrahim Halil, Ceyhan, Koksal, Erkorkmaz, Unal
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Aorta - diagnostic imaging
Aorta - physiopathology
Asymptomatic Diseases
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
C-Reactive Protein - analysis
Cardiology. Vascular system
Cardiovascular
Cardiovascular system
Carotid Arteries - diagnostic imaging
Carotid Arteries - physiopathology
Carotid Intima-Media Thickness
Case-Control Studies
Coronary Artery Disease - blood
Coronary Artery Disease - diagnosis
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Coronary Artery Disease - genetics
Coronary Artery Disease - physiopathology
Echocardiography, Doppler, Pulsed
Elasticity
Fathers
Female
Genetic Predisposition to Disease
Heredity
High-sensitivity C-reactive protein
Homocysteine
Homocysteine - blood
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Pedigree
Phenotype
Pulsatile Flow
Pulse wave velocity
Risk Assessment
Risk Factors
Stiffness index
Turkey - epidemiology
Ultrasonic investigative techniques
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Summary:Highlights ► We aimed to evaluate the adolescents who are at high risk of premature atherosclerosis. ► Thirty-three subjects who have a father with a history of obstructive coronary artery disease before the age 40 and 30 controls were enrolled to the study. ► Carotid intima-media thickness and pulse wave velocity values were higher in the risky group, but these differences were not statistically significant. ► Present methods failed to show expected subclinical atherosclerosis in risky adolescents.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2012.03.026