Cancer incidence and pattern of arsenic concentration in drinking water wells in Córdoba, Argentina

Cancer occurrence is associated with Arsenic (As) in drinking water. In Argentina, there are high As concentrations in groundwater but there is no published evidence yet of an association between geographic patterns of cancer incidence and the distribution of As in groundwater supplies. The purpose...

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Bibliographic Details
Published in:International journal of environmental health research 2012-06, Vol.22 (3), p.220-231
Main Authors: Aballay, Laura Rosana, Díaz, María del Pilar, Francisca, Franco Matías, Muñoz, Sonia Edith
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Aquifers
Argentina
Argentina - epidemiology
Arsenic - analysis
Arsenic - toxicity
Arsenic content
arsenic exposure
cancer incidence
Child
Child, Preschool
Drinking water
Drinking Water - analysis
Drinking Water - standards
Environmental Monitoring - statistics & numerical data
Epidemiological Monitoring
Female
Groundwater
Humans
Incidence
Infant
Infant, Newborn
Male
Middle Aged
Neoplasms - epidemiology
Neoplasms - etiology
Registries
Risk factors
Sex Factors
spatial distribution
Water Pollutants, Chemical - analysis
Water Pollutants, Chemical - toxicity
Water Wells - analysis
Water Wells - standards
Wells
Young Adult
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Summary:Cancer occurrence is associated with Arsenic (As) in drinking water. In Argentina, there are high As concentrations in groundwater but there is no published evidence yet of an association between geographic patterns of cancer incidence and the distribution of As in groundwater supplies. The purpose of this study is to assess the association between cancer incidence patterns and As in Córdoba province's aquifers. Age standardized incidence rates (ASIRs) were obtained from Córdoba Cancer Registry (CCR), and As data from official reports of monitoring wells. A multilevel model was applied. Total ASIRs by aquifers for males/females were 191.01/249.22 (Rioja plain); 215.03/225.37 (Pampa hills); and 239.42/188.93 (Chaco-Pampa plain). As was associated with increased risk of colon cancer in women, and lung and bladder cancers in both sexes. It had no association with breast cancer. ASIRs were related to As, controlling for unobserved heterogeneity. An overlapping pattern of higher As and higher risks was evident for lung, bladder and female colon cancers.
ISSN:0960-3123
1369-1619
DOI:10.1080/09603123.2011.628792