A detailed association analysis between the tryptophan hydroxylase 2 ( TPH2 ) gene and autism spectrum disorders in a Japanese population

Abstract We conducted a detailed association analysis between the tryptophan hydroxylase 2 gene and autism spectrum disorders in a Japanese population using 19 markers, including tagging single nucleotide polymorphisms and a novel missense variation, p.R225Q, identified through exon resequencing. Ho...

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Bibliographic Details
Published in:Psychiatry research 2012-04, Vol.196 (2), p.320-322
Main Authors: Egawa, Jun, Watanabe, Yuichiro, Nunokawa, Ayako, Endo, Taro, Kaneko, Naoshi, Tamura, Ryu, Sugiyama, Toshiro, Someya, Toshiyuki
Format: Article
Language:English
Subjects:
Adolescent
Adult
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Child
Child clinical studies
Child Development Disorders, Pervasive - diagnosis
Child Development Disorders, Pervasive - epidemiology
Child Development Disorders, Pervasive - genetics
Developmental disorders
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease - genetics
Genotype
Humans
Infantile autism
Japan - epidemiology
Male
Medical sciences
Middle Aged
Missense variation
Polymorphism, Single Nucleotide - genetics
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Resequencing
Tagging SNPs
Tryptophan Hydroxylase - genetics
Young Adult
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Summary:Abstract We conducted a detailed association analysis between the tryptophan hydroxylase 2 gene and autism spectrum disorders in a Japanese population using 19 markers, including tagging single nucleotide polymorphisms and a novel missense variation, p.R225Q, identified through exon resequencing. However, we failed to obtain supportive evidence for an association.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2011.09.001