Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle

Zeolitic Imidazolate Framework-8 (ZIF-8), for the first time for ZIFs, exhibits a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), around 660 mg of 5-FU/g of ZIF-8, and presents a pH-triggered controlled drug release property. These prove ZIF-8 to be a valuable candidate for delive...

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Published in:Dalton transactions : an international journal of inorganic chemistry 2012-06, Vol.41 (23), p.696-699
Main Authors: Sun, Chun-Yi, Qin, Chao, Wang, Xin-Long, Yang, Guang-Sheng, Shao, Kui-Zhan, Lan, Ya-Qian, Su, Zhong-Min, Huang, Peng, Wang, Chun-Gang, Wang, En-Bo
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Drug Carriers - chemistry
Fluorouracil - chemistry
Hydrogen-Ion Concentration
Imidazoles - chemistry
Models, Molecular
Molecular Conformation
Zeolites - chemistry
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Summary:Zeolitic Imidazolate Framework-8 (ZIF-8), for the first time for ZIFs, exhibits a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), around 660 mg of 5-FU/g of ZIF-8, and presents a pH-triggered controlled drug release property. These prove ZIF-8 to be a valuable candidate for delivery of anticancer agents and reveal its potential applications in the treatment of cancer. ZIF-8, for the first time for ZIFs, we present a pH-triggered controlled drug release property and remarkable capacity.
ISSN:1477-9226
1477-9234
DOI:10.1039/c2dt30357d