rise of mutation level in tissues of monkey goby and sturgeon fry under conditions of block by antibodies to the serotonin-modulated anticonsolidation protein

The work presents data on studies of effect of a decrease in the serotoninergic system activity on the level of mutagenic changes (the micronuclear test) in the goby Neogobius fluviatilis and the fry of sturgeon Acipenser güldenstädti persicus. It has been shown that the long exposure of the animals...

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Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology 2010-10, Vol.46 (5), p.447-452
Main Authors: Mekhtiev, A. A, Palatnikov, G. M, Movsum-zadeh, S. K, Kasimov, R. Yu
Format: Article
Language:English
Subjects:
Acipenser
Acipenser gueldenstaedti
Animal Physiology
Biochemistry
Biomedical and Life Sciences
Brackish
Comparative and Ontogenic Biochemistry
Evolutionary Biology
Fish
Life Sciences
Mutation
Neogobius fluviatilis
Serotonin
Water pollution
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Summary:The work presents data on studies of effect of a decrease in the serotoninergic system activity on the level of mutagenic changes (the micronuclear test) in the goby Neogobius fluviatilis and the fry of sturgeon Acipenser güldenstädti persicus. It has been shown that the long exposure of the animals to conditions of industrial and oil pollution leads to a significant decrease in their liver of the level of serotonin-modulated anticonsolidation protein (SMAP) correlating directly with the serotonin level as well as to a sharp rise of the level of micronuclear in erythrocytes. The intramuscular administration of anti-SMAP polyclonal antibodies to the sturgeon fry produces a significant increase of the amount of micronuclear as compared with that in the animals injected with non-immune γ-globulin. The obtained results allow concluding that the decrease of activity of the serotoninergic system is the mechanism that is triggered with adverse environmental factors and realizes mutagenic damages in the modified genetic apparatus.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093010050038