Extended gastritis cystica profunda associated with Epstein‐Barr virus‐positive dysplasia and carcinoma with lymphoid stroma

We report a case of gastritis cystica porfunda (GCP) associated with gastric carcinoma with lymphoid stroma (CLS). There was dysplastic change in the transitional area between GCP and CLS. Epstein‐Barr virus (EBV) in situ hybridization (ISH) revealed positive reaction at the dysplastic area as well...

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Bibliographic Details
Published in:Pathology international 2012-05, Vol.62 (5), p.351-355
Main Authors: Kim, Lucia, Kim, Joon Mee, Hur, Yoon Seok, Shin, Yong Woon, Park, In Suh, Choi, Suk Jin, Han, Jee Young, Chu, Young Chae, Kim, Kyu Ho
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adenocarcinoma - virology
Biomarkers, Tumor
Carcinoembryonic antigen
Carcinoma
carcinoma with lymphoid stroma
Case reports
Cysts - pathology
Dysplasia
E-Cadherin
Epithelium
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - pathology
Epstein-Barr Virus Infections - surgery
Foreign-Body Reaction - etiology
Foreign-Body Reaction - pathology
Foreign-Body Reaction - surgery
Gastrectomy
Gastric cancer
Gastritis
Gastritis - pathology
Gastritis - virology
gastritis cystica profunda
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - isolation & purification
Humans
In Situ Hybridization
Infection
Lymphoid Tissue - pathology
Lymphoid Tissue - virology
Male
Middle Aged
p53 protein
Precancerous Conditions - pathology
Precancerous Conditions - surgery
Precancerous Conditions - virology
RNA, Viral - analysis
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Stomach Neoplasms - virology
Stroma
Stromal Cells - pathology
Stromal Cells - virology
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Summary:We report a case of gastritis cystica porfunda (GCP) associated with gastric carcinoma with lymphoid stroma (CLS). There was dysplastic change in the transitional area between GCP and CLS. Epstein‐Barr virus (EBV) in situ hybridization (ISH) revealed positive reaction at the dysplastic area as well as at the CLS area. Immunohistochemical staining disclosed that dysplastic epithelium was similar to GCP in CK 20, MUC5AC, and E‐cadherin expression, but similar to CLS in MUC6, CEA, p53, c‐erb‐B2, and EBV‐ISH expression. Results of the EBV‐ISH suggested that EBV infection may play a role in dysplastic change.
ISSN:1320-5463
1440-1827
DOI:10.1111/j.1440-1827.2012.02806.x